Epilepsy and the ketogenic diet: Assessment of ketosis in children using breath acetone

被引：26

作者：

Musa-Veloso K. ^{[1
]}

Rarama E. ^{[1
]}

Comeau F. ^{[1
]}

Curtis R. ^{[1
]}

Cunnane S. ^{[1
]}

机构：

[1] Department of Nutritional Sciences, University of Toronto, Toronto, Ont. M5S 3E2

来源：

Pediatric Research | 2002年 / 52卷 / 3期

关键词：

D O I：

10.1203/00006450-200209000-00023

中图分类号：

学科分类号：

摘要：

High-fat ketogenic diets increase ketones (acetoacetate, β-hydroxybutyrate, and acetone) and are used to treat refractory seizures. Although ketosis is an integral aspect of these therapeutic regimens, the direct importance of ketosis to seizure control needs further investigation. An examination of this relationship requires a reliable, minimally invasive measure of ketosis that can be performed frequently. In the present study, we examined the use of breath acetone as a measure of ketosis in children with refractory seizures on a classic ketogenic diet. Results were compared with breath acetone levels in epilepsy and healthy controls. Children on the ketogenic diet had significantly higher fasting breath acetone compared with epilepsy or healthy controls (2530 ± 600 nmol/L versus 19 ± 9 nmol/L and 21 ± 4 nmol/L, respectively; p < 0.05). One hour after consumption of a ketogenic breakfast meal, breath acetone increased significantly in epilepsy and healthy controls (p < 0.05), but not in children on a ketogenic diet. Children who were on the ketogenic diet for longer periods of time had a significantly lower fasting breath acetone (R2 = 0.55, p = 0.014). In one child on the ketogenic diet, breath acetone was determined hourly over a 9-h period, both by gas chromatography and by a prototype hand-held breath acetone analyzer. Preliminary results using this hand-held breath acetone analyzer are encouraging. Breath acetone may be a useful tool in examining the relationship between ketosis and seizure control and enhancing our understanding of the mechanism of the ketogenic diet.

引用

页码：443 / 448

页数：5

共 31 条

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