The genetics of adiponectin

被引：89

作者：

Francis Vasseur

Frédéric Leprêtre

Corinne Lacquemant

Philippe Froguel

机构：

[1] CNRS UMR 8090, Institut de Biologie de Lille, F-59021 Lille Cedex

来源：

Current Diabetes Reports | 2003年 / 3卷 / 2期

基金：

英国医学研究理事会;

关键词：

Insulin Resistance; Genetic Modulation; Adiponectin Level; Insulin Resistance Syndrome; Serum Adiponectin Level;

D O I：

10.1007/s11892-003-0039-4

中图分类号：

学科分类号：

摘要：

Adiponectin encoded by the APM1 gene is one of the adipocyte-expressed proteins that function in the homeostatic control of glucose, lipid, and energy metabolism. Its dysregulation has been suggested to be involved in disorders covering the metabolic X syndrome, such as insulin resistance, obesity, type 2 diabetes, and coronary artery disease. Recent data present evidence of a genetic modulation of the adiponectin level, and linkage of the 3q27 locus, where the APM1 gene lies, with diabetes and features of the metabolic X syndrome playing a putative role of the APM1 gene in this syndrome. In this article, we present an overview of the results available to date and discuss positive evidence for a role of genetic variants of the APM1 gene and questions that genetic data raise. Copyright © 2003 by Current Science Inc.

引用

页码：151 / 158

页数：7

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