Inflammation as a mechanism and therapeutic target for in-stent restenosis

被引：87

作者：

Drachman D.E. ^{[1
]}

Simon D.I. ^{[1
]}

机构：

[1] Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114

来源：

Current Atherosclerosis Reports | 2005年 / 7卷 / 1期

关键词：

Percutaneous Coronary Intervention; Sirolimus; Stent Implantation; Probucol; Arterioscler Thromb Vasc Biol;

D O I：

10.1007/s11883-005-0074-5

中图分类号：

学科分类号：

摘要：

Restenosis following coronary stenting has long been attributed to neointimal proliferation, thrombosis, and negative remodeling. More recently, the important role of inflammation in vascular healing has also been increasingly well understood. From animal models and from clinical experience, we know that endothelial injury, platelet and leukocyte interactions, and subcellular chemoattractant and inflammatory mediators are pivotal in the development of the inflammatory response following stent implantation. By examining the specific mechanisms governing the inflammatory response to percutaneous coronary intervention, we may gain insight into potential therapeutic targets and strategies to prevent restenosis in clinical practice. Copyright © 2005 by Current Science Inc.

引用

页码：44 / 49

页数：5

共 49 条

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