Traveler's diarrhea: Modern concepts and new developments

被引:10
作者
DuPont A.W. [1 ]
DuPont H.L. [1 ]
机构
[1] University of Texas Medical Branch, Galveston, TX 77555-0764
关键词
Diarrhea; Irritable Bowel Syndrome; Azithromycin; Rifaximin; Extraintestinal Infection;
D O I
10.1007/s11938-006-0020-9
中图分类号
学科分类号
摘要
Travelers' diarrhea occurs when persons move from industrialized regions to developing countries with reduced hygiene. Bacterial enteropathogens from ingested food are the primary causes. Although it is possible to reduce the occurrence of illness by careful selection of food and beverages, travelers do not seem willing to restrict their diets. Diarrhea is associated with a disability of 24 hours per episode, interfering with travel plans and, of even greater concern, post-diarrhea irritable bowel syndrome (IBS) occurs in up to 10% of patients. The use of rifaximin, a poorly absorbed drug, is likely to become common as an attempt to prevent diarrhea and post-infectious IBS. All travelers to high-risk areas should take with them an effective antibacterial drug (rifaximin, fluoroquinolones, or azithromycin) for self-treatment of diarrhea occurring during travel. Additional work is needed to improve the hygienic conditions found in the developing world into which susceptible persons travel. Copyright © 2006 by Current Science Inc.
引用
收藏
页码:13 / 21
页数:8
相关论文
共 51 条
[1]  
Jiang Z.D., Lowe B., Verenkar M.P., Et al., Prevalence of enteric pathogens among international travelers with diarrhea acquired in Kenya (Mombasa), India (Goa), or Jamaica (Montego Bay), J Infect Dis, 185, pp. 497-502, (2002)
[2]  
DuPont H.L., Ericsson C.D., Prevention and treatment of traveler's diarrhea, N Engl J Med, 328, pp. 1821-1827, (1993)
[3]  
Adachi J.A., Mathewson J.J., Jiang Z.D., Et al., Enteric pathogens in Mexican sauces of popular restaurants in Guadalajara, Mexico, and Houston, Texas, Ann Intern Med, 136, pp. 884-887, (2002)
[4]  
Kozicki M., Steffen R., Schar M., Boil it, cook it, peel it or forget it': Does this rule prevent travellers' diarrhoea?, Int J Epidemiol, 14, pp. 169-172, (1985)
[5]  
Tjoa W.S., DuPont H.L., Sullivan P., Et al., Location of food consumption and travelers' diarrhea, Am J Epidemiol, 106, pp. 61-66, (1977)
[6]  
Adachi J.A., Ericsson C.D., Jiang Z.D., Et al., Natural history of enteroaggregative and enterotoxigenic Escherichia coli infection among US travelers to Guadalajara, Mexico, J Infect Dis, 185, pp. 1681-1683, (2002)
[7]  
Adachi J.A., Jiang Z.D., Mathewson J.J., Et al., Enteroaggregative Escherichia coli as a major etiologic agent in traveler's diarrhea in 3 regions of the world, Clin Infect Dis, 32, pp. 1706-1709, (2001)
[8]  
Hoge C.W., Gambel J.M., Srijan A., Et al., Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15 years, Clin Infect Dis, 26, pp. 341-345, (1998)
[9]  
Caeiro J.P., Estrada-Garcia M.T., Jiang Z.D., Et al., Improved detection of enterotoxigenic Escherichia coli among patients with travelers' diarrhea, by use of the polymerase chain reaction technique, J Infect Dis, 180, pp. 2053-2055, (1999)
[10]  
DuPont H.L., Ericsson C.D., Mathewson J.J., Et al., Oral aztreonam, a poorly absorbed yet effective therapy for bacterial diarrhea in US travelers to Mexico, JAMA, 267, pp. 1932-1935, (1992)