The molecular pathogenesis of Clostridium difficile-associated disease

被引：4

作者：

David A. Bobak

机构：

[1] Division of Infectious Diseases and HIV Medicine, Case School of Medicine, University Hospital-Case Medical Center, Cleveland, OH 44106

来源：

Current Infectious Disease Reports | 2008年 / 10卷 / 2期

关键词：

Oxin; Toxin Expression; Stal Structure; Tcds;

D O I：

10.1007/s11908-008-0020-0

中图分类号：

学科分类号：

摘要：

Clostridium difficille-associated disease is a reemerging nosocomial disease of paramount importance not only in the United States, but most of the world as well. Recently, C. difficile-associated disease appears to be on the rise, with a parallel increase noted in its severity and extent. Although the main virulence factors, the large exotoxins known as toxin A and toxin B, have long been identified, only in the past few years has a near explosion of new information regarding the details of the toxin-mediated pathogenicity come to light. This update gives an overview of some of the more exciting and insightful reports published in the recent literature. Copyright © 2008 by Current Medicine Group LLC.

引用

页码：111 / 115

页数：4

共 43 条

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