Seasonal variations in markers of stress and oxidative stress in rats

被引：25

作者：

Bhat S. ^{[1
]}

Rao G. ^{[1
]}

Murthy K.D. ^{[2
]}

Bhat P.G. ^{[3
]}

机构：

[1] Department of Biochemistry, Melaka Manipal Medical College (Manipal Campus)

[2] Department of Physiology, Melaka Manipal Medical College (Manipal Campus)

[3] Department of Biochemistry, Kasturba Medical College

来源：

Indian Journal of Clinical Biochemistry | 2008年 / 23卷 / 2期

关键词：

Antioxidants; Cortisol; Oxidative stress; Season; Temperature;

D O I：

10.1007/s12291-008-0042-2

中图分类号：

学科分类号：

摘要：

High ambient temperature has been reported to increase oxidative stress by increasing lipid peroxidation and decreasing antioxidant defence in transition dairy cows. It is also known to cause an increase in plasma cortisol levels in goats, European hedgehog and human volunteers. High levels of glucocorticoids have been reported to decrease blood glutathione and erythrocyte superoxide dismutase activity in rats. Although institutional animal houses in research laboratories of developed countries maintain animals in air-conditioned rooms at constant temperature, the same is not true of animal houses in the developing countries especially those belonging to smaller institutions and this could affect the results of the experiments being conducted on these animals. The present research study was done to assess the effects of seasonal variations on the status of erythrocyte oxidative damage, antioxidant defence and plasma cortisol levels in adult female Wistar rats. Rats were kept in their home cages and were left in non-air-conditioned procedure rooms in two different seasons, Hot season (March-May) and Cool season (June to September). Erythrocyte Thiobarbituric acid reactive substances and plasma cortisol levels were significantly increased in rats exposed to high ambient temperature and humidity of the hot season as compared to the rats of the cool season. Erythrocyte reduced glutathione levels, erythrocyte glutathione peroxidase and superoxide dismutase activities were significantly decreased in the hot season group of rats. The results of our experiments showed that exposure of adult female Wistar rats to high ambient temperature and humidity of the hot season increases neuroendocrine stress, oxidative stress and decreases antioxidant defence in them.

引用

页码：191 / 194

页数：3

共 24 条

[1]

Cross C.E., Halliwell B., Borish E.T., Pryor W.A., Ames B.N., Saul R.L., Et al., Oxygen radicals and human disease, Ann Intern Med, 107, pp. 526-545, (1987)

[2]

Gutteridge J.M.C., Lipid peroxidation and antioxidants as biomarkers of tissue damage, Clin Chem, 41, 12, pp. 1819-1828, (1995)

[3]

Sies H., Antioxidants in disease mechanisms and therapy, Advances in Pharmacology, 38, (1997)

[4]

Aleksandrovskii I.A., Poiurovskii M.V., Neznamov G.G., Seredeniia S.B., Krasova E.A., Lipid peroxidation in emotional stress and neurotic Disorders, Zhurnal Nevropatologii I pshikiatrii Imeni SS Korsakova, 88, 11, pp. 95-101, (1988)

[5]

Orzechowski A., Ostaszewski P., Brodnicka A., Wiczak M., Jank B., Balasmska K., Et al., Excess of glucocorticoids impairs whole-body antioxidant status in young rats-relation to the effect of dexamethasone in soleus muscle and spleen, Horm Metab Res, 32, 5, pp. 174-180, (2000)

[6]

Bernabucci U., Ronchi B., Lacetera N., Nardone A., Markers of oxidative status in plasma and erythrocytes of transition dairy cows during hot season, J Dairy Sci, 85, 9, pp. 2173-2179, (2002)

[7]

Hao W.W., Qin S.Z., Yu Q.F., Li M.G., Ma G.X., Zhao H., Effects of heat and noise environments on lipid peroxidation of erythrocyte membrane in pilots, Space Med Eng, 13, 1, pp. 52-54, (2000)

[8]

Alila Johanasson A., Erikson L., Soveri T., Laakso M.L., Serum cortisol levels in goats exhibit seasonal but not daily rhythmicity, Chronobiol Int, 20, 1, pp. 65-79, (2003)

[9]

Fowler P.A., Seasonal endocrine cycles in the European hedgehog, Erinaceus europaeus, J Reprod Ferti, 84, 1, pp. 259-272, (1988)

[10]

Hansen A.M., Garde A.H., Skovgaard L.T., Christensen J.M., Seasonal and biological variation of urinary epinephrine, norepinephrine and cortisol in healthy women, Clin Chim Acta, 309, 1, pp. 25-35, (2001)

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