Self-assessment of somatic and psychic symptoms during a two months period of hormone replacement therapy in perimenopausal women

被引：5

作者：

Banger M. ^{[1
,3
]}

Rimpel J. ^{[1
]}

Lodemann E. ^{[1
]}

Feldmann H.U. ^{[2
]}

Gastpar M. ^{[1
]}

机构：

[1] Department of Psychiatry, University of Essen

[2] Practice of Gynaecology, Essen

[3] Department of Psychiatry, University of Essen, D-45147 Essen

来源：

Archives of Women's Mental Health | 1999年 / 1卷 / 4期

关键词：

Hormone replacement therapy; Menopause; Psychopathology; Self-assessment;

D O I：

10.1007/s007370050026

中图分类号：

学科分类号：

摘要：

The drastic decrease in sex steroids production at menopause is often related to the development of somatic and psychic symptoms in women. We examined the effects of a two months hormone replacement therapy (HRT) on weekly self-assessments of menopausal symptoms, mood and sleep disturbances. In addition, spatial perception and motor performances abilities were measured before and after 8 weeks of HRT. Twentythree healthy perimenopausal women (mean 50 ± 4.8 years of age) with no previous hormone therapy and a Kuppermann-Index ≥15 were included. Before therapy and in weekly intervals during two months of treatment women reported upon their menopausal symptoms (MENOI), their mood state (POMS) and sleep disturbances (VISM). Psychological examinations were done before HRT and two months later under hormone replacement therapy. All 23 patients showed a significant improvement of the self report of climacteric, affective symptoms and of sleep disturbances, and a tendency to improvement in cognitive performance with respect to pretreatment measures. This indicates that hormone replacement therapy in perimenopausal women is associated with clinical improvement in somatic and psychic symptoms and a cognitive enhancement in some aspects. These benefits of the HRT must play a role in cost-effectiveness analyses of HRT.

引用

页码：183 / 187

页数：4

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