Marked elevation of vascular endothelial growth factor and basic fibroblast growth factor in pericardial fluid of patients with angina pectoris

被引：21

作者：

Fujita M. ^{[1
,5
]}

Ikemoto M. ^{[1
]}

Tanaka T. ^{[2
]}

Tamaki S.-I. ^{[2
]}

Yamazato A. ^{[2
]}

Sawamura T. ^{[3
]}

Hasegawa K. ^{[4
]}

Kihara Y. ^{[4
]}

Nohara R. ^{[4
]}

Sasayama S. ^{[4
]}

机构：

[1] College of Medical Technology, Kyoto University

[2] Takeda Hospital, Kyoto University, Graduate School of Medicine

[3] Department of Pharmacology, Kyoto University, Graduate School of Medicine

[4] Dept. of Cardiovascular Medicine, Kyoto University, Graduate School of Medicine

[5] College of Medical Technology, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606-01

来源：

Angiogenesis | 1998年 / 2卷 / 1期

基金：

日本学术振兴会;

关键词：

Angiogenesis; Collateral circulation; Coronary artery bypass graft surgery; Stable angina; Unstable angina;

D O I：

10.1023/A:1009062712441

中图分类号：

学科分类号：

摘要：

Although we reported that basic fibroblast growth factor (bFGF) levels in pericardial fluid of patients with unstable angina are apparently increased, it was unclear whether vascular endothelial growth factor (VEGF) is also increased in patients with myocardial ischemia. Using an enzyme-linked immunosorbent assay, we measured the concentrations of VEGF and bFGF in pericardial fluid of 51 patients with open heart surgery. Patients were divided into group A (n = 10) with class III unstable angina (Braunwald's classification), group B (n = 24) with class I or II unstable angina or stable angina and group C (n = 17) with non-ischemic heart disease. The VEGF level in pericardial fluid in group A was 83 ± 7 pg/ml, being significantly (p < 0.001) higher than the 27 ± 3 pg/ml in group B and the 28 ± 5 pg/ml in group C. The concentrations of bFGF in pericardial fluid in groups A and B were 1461 ± 579 and 1224 ± 161 pg/ml, respectively, significantly (p < 0.05) higher than the 292 ± 97 pg/ml in group C. The level of VEGF in pericardial fluid was increased only in patients with severe rest angina within 2 days before emergency coronary artery bypass graft surgery (CABG), while bFGF was increased in all patients undergoing CABG for coronary artery disease. Thus VEGF and bFGF may play important roles in mediating collateral growth in humans. [© 1998 Rapid Science Ltd.].

引用

页码：105 / 108

页数：3

共 13 条

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