Guadinomines, type III secretion system inhibitors, produced by Streptomyces sp. K01-0509: II. Physico-chemical properties and structure elucidation

被引：41

作者：

Iwatsuki M. ^{[1
]}

Uchida R. ^{[1
,3
]}

Yoshijima H. ^{[2
]}

Ui H. ^{[2
]}

Shiomi K. ^{[2
]}

Matsumoto A. ^{[1
]}

Takahashi Y. ^{[2
]}

Abe A. ^{[2
]}

Tomoda H. ^{[2
,3
]}

Omura S. ^{[1
]}

机构：

[1] Kitasato Institute, Minato-ku, Tokyo 108-8642

[2] Kitasato Institute for Life Sciences, Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641

[3] School of Pharmacy, Kitasato University, Minato-ku, Tokyo 108-8641

来源：

The Journal of Antibiotics | 2008年 / 61卷 / 4期

关键词：

EPEC; Guadinomines; Streptomyces sp. K01-0509; Type III secretion system;

D O I：

10.1038/ja.2008.33

中图分类号：

学科分类号：

摘要：

The structures of guadinomines, new inhibitors of a bacterial Type III secretion system produced by Streptomyces sp. K01-0509, were elucidated by spectroscopic studies including various NMR experiments. Guadinomines A, B, C1, C2 and D consist of a carbamoylated cyclic guanidinyl moiety, an alkyl chain moiety and an L-Ala-L-Val moiety in common, while guadinomic acid is a smaller molecule consisting of a carbamoylated cyclic guanidinyl moiety and a hydroxyl hexanoate moiety. © Japan Antibiotics Research Association.

引用

页码：230 / 236

页数：6

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