Progress in high throughput SNP genotyping methods

被引：102

作者：

Tsuchihashi Z. ^{[1
]}

Dracopoli N.C. ^{[1
]}

机构：

[1] Clinical Discovery Technologies, Bristol-Myers Squibb Co., Princeton, NJ 08543-5400

来源：

The Pharmacogenomics Journal | 2002年 / 2卷 / 2期

关键词：

D O I：

10.1038/sj.tpj.6500094

中图分类号：

学科分类号：

摘要：

Most current single nucleotide polymorphism (SNP) genotyping methods are still too slow and expensive for routine use in large association studies with hundreds or more SNPs in a large number of DNA samples. However, SNP genotyping technology is rapidly progressing with the emergence of novel, faster and cheaper methods as well as improvements in the existing methods. In this review, we focus on technologies aimed at high throughput uses, and discuss the technical advances made in this field in the last few years. The rapid progress in technology, in combination with the discovery of millions of SNPs and the development of the human haplotype map, may enable whole genome association studies to be initiated in the near future.

引用

页码：103 / 110

页数：7

共 94 条

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