In vitro activity of gemifloxacin (SB-265805) compared to eleven other antimicrobial agents against streptococcal isolates, excluding Streptococcus pneumoniae

被引：7

作者：

Kerawala M. ^{[1
]}

Ambler J.E. ^{[2
]}

Lee P.Y.C. ^{[1
]}

Drabu Y.J. ^{[1
]}

机构：

[1] Department of Microbiology, North Middlesex Hospital NHS Trust, Edmonton, London N18 1QX, Sterling Way

[2] SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AW, New Frontiers Science Park (South)

来源：

European Journal of Clinical Microbiology and Infectious Diseases | 2001年 / 20卷 / 4期

关键词：

Levofloxacin; Streptococcus Pneumoniae; Streptococcus Mutans; Sparfloxacin; Trovafloxacin;

D O I：

10.1007/PL00011264

中图分类号：

学科分类号：

摘要：

The purpose of the study presented here was to determine the in vitro activity of gemifloxacin compared with that of 11 other antimicrobial agents (5 of them quinolones) against 400 isolates of β-haemolytic and viridans group streptococci. The minimum inhibitory concentration values for gemifloxacin against 90% of the streptococci tested were as follows: Lancefield groups A, C and G, 0.06 μg/ml; Lancefield group B, Streptococcus mitis, Streptococcus mutans and Streptococcus bovis, 0.125 μg/ml; and Streptococcus milleri, 0.03 μg/ml. Resistance to penicillin, ampicillin and erythromycin was found mainly in the Streptococcus mitis isolates; tetracycline showed variable results, and no vancomycin resistance was encountered. Higher rates of ciprofloxacin resistance were identified in the Streptococcus bovis, mitis and mutans isolates. In conclusion, gemifloxacin was the most active quinolone tested followed by trovafloxacin, sparfloxacin, grepafloxacin, ciprofloxacin and levofloxacin, especially against isolates resistant to β-lactam agents, macrolides and tetracycline.

引用

页码：271 / 275

页数：4

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