Lipometabolic disorder - Cholesterol and triglycerides

Resorption inhibitors for cholesterol are commonly applied today in case of hypercholesterolemia in addition to statins. This combination therapy reduces the value of the LDL concentration by 50-60%. A target value of 100 mg/dl should be adjusted in case of high-risk patients in order to also decrease coronary risk. The significance of the triglycerides level is also becoming increasingly important, for it describes a high cardiovascular risk due to an increase of adiposity and diabetes. Such a dysfunction in storage and release of fatty lipids from triglycerides is treated dependent on severity: Patients with slightly elevated values (> 200 mg/dl) should change their habits (e.g. balanced diet, abstinance of alcohol, exercise) if necessary followed by application of fibrates, omega-3 fatty acids or nicotinic acid. These medicamentous measures are inevitable and must be applied immediately in case patients having values >1000 mg/dl. © 2006 Steinkopff-Verlag.