Prostatic intraepithelial neoplasia in prostate specimens: Frequency, significance and relationship to the sampling of the specimen (A retrospective study of 121 cases)

被引：17

作者：

Aydin Ö. ^{[1
]}

Coşar E.F. ^{[2
]}

Varinli S. ^{[2
]}

Buǧdayci R. ^{[3
]}

Tansuǧ Z. ^{[4
]}

机构：

[1] Department of Pathology, Mersin University, Faculty of Medicine, Mersin

[2] Department of Pathology, Çukurova University, Faculty of Medicine, Adana

[3] Department of Public Health, Mersin University, Faculty of Medicine, Mersin

[4] Department of Urology, Çukurova University, Faculty of Medicine, Adana

来源：

International Urology and Nephrology | 1999年 / 31卷 / 5期

关键词：

Public Health; Carcinoma; Retrospective Study; Paraffin; Bladder Cancer;

D O I：

10.1023/A:1007120907921

中图分类号：

学科分类号：

摘要：

Objectives: To determine the frequency of PIN (prostatic intraepithelial neoplasia) in prostate specimens and the relationship of PIN with PCA (prostatic carcinoma) and amount of sampling of the specimen. Materials and methods: All the haematoxylin-eosin stained slides of 121 cases diagnosed between 1990 and 1995 were re-examined retrospectively. The amount of sampling of prostate specimens was also re-examined. Results: PIN was observed in 47.9% of all prostate specimens. The frequency of incidental PIN was 71.4% in cystoprostatectomy specimens. PIN was present in 58.3% of the cases with PCA. We observed foci of high-grade PIN adjacent to sites of invasive carcinoma in 100.0% of prostatectomy specimens with PCA. PIN was high-grade in 100.0% of the carcinomatous prostates with PIN. It was multifocal in 53.4% of 58 cases with PIN. Incidental PCA was identified in 14.3% of cytoprostatectomies for bladder cancer. The average number of paraffin blocks of prostatic tissue was 4.1 (±2.6) in cases with PIN and 3.2 (±1.4) in cases without PIN. Conclusion: In prostate specimens, the determination of PIN is very important since it is the most likely precursor of PCA. The probability of detecting PIN and PCA in a prostate specimen is directly related to the amount of sampling.

引用

页码：687 / 697

页数：10

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