Adenosquamous Carcinoma of the Head and Neck: Relationship to Human Papillomavirus and Review of the Literature

被引：77

作者：

Masand R.P. ^{[1
]}

El-Mofty S.K. ^{[1
]}

Ma X.-J. ^{[2
]}

Luo Y. ^{[2
]}

Flanagan J.J. ^{[2
]}

Lewis Jr. J.S. ^{[1
]}

机构：

[1] Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110

[2] Advanced Cell Diagnostics, Inc., Hayward, CA 94545

来源：

Head and Neck Pathology | 2011年 / 5卷 / 2期

关键词：

Adenosquamous carcinoma; Human papillomavirus; p16; p53;

D O I：

10.1007/s12105-011-0245-3

中图分类号：

学科分类号：

摘要：

Adenosquamous carcinoma (ADSC) of the head and neck is an aggressive variant of squamous cell carcinoma (SCC). Certain variants of head and neck SCC are human papillomavirus (HPV)-related and have better prognosis. The relationship of HPV to head and neck ADSC has not been investigated. We searched our files for the term adenosquamous and head and neck subsites and found cases from 1998 to 2009. The requisite histologic criteria were the presence of SCC combined with distinct gland formation and/or intracellular mucin. DNA in situ hybridization for high-risk HPV, RNA in situ hybridization for high risk HPV E6 and E7 transcripts, and immunohistochemistry for p16 and p53 were performed. The existing literature on ADSC was also reviewed. Of the 18 cases, eight were from the larynx and hypopharynx, four from the oral cavity, three from the oropharynx, and three from the nasal cavity. Three cases (16%) showed both high risk HPV E6 and E7 and p16 expression, one from the nasal cavity and two from the oropharynx. Both oropharyngeal carcinoma patients were alive and disease free at 34 and 103 months, respectively. ADSCs of the head and neck are a heterogeneous group of tumors. A small minority of cases harbor HPV and most of these, particularly those occurring at sites with known high prevalence of HPV, show active viral transcription with detectable E6 and E7 and overexpression of p16. The HPV-related oropharyngeal cases, though rare, appear to do very well clinically, while the remaining cohort of ADSC patients do quite poorly. Head and neck ADSC appears to be a mixed variant that can be further classified according to its HPV status. © 2011 Springer Science+Business Media, LLC.

引用

页码：108 / 116

页数：8

共 44 条

[1]

Cardesa A., Zidar N., Alos L., Adenosquamous carcinoma, Pathology and Genetics Head and Neck Tumours, pp. 130-131, (2005)

[2]

Slootweg P.J., Richardson M., Squamous cell carcinoma of the upper aerodigestive system, Diagnostic Surgical Pathology of the Head and Neck, pp. 88-91, (2009)

[3]

Damiani J.M., Damiani K.K., Hauck K., Et al., Mucoepidermoid-adenosquamous carcinoma of the larynx and hypopharynx: A report of 21 cases and a review of the literature, Otolaryngol Head Neck Surg, 89, 2, pp. 235-243, (1981)

[4]

Gerughty R.M., Hennigar G.R., Brown F.M., Adenosquamous carcinoma of the nasal, oral and laryngeal cavities. A clinicopathologic survey of ten cases, Cancer, 22, 6, pp. 1140-1155, (1968)

[5]

Chernock R.D., El-Mofty S.K., Parvin C.A., Lewis J.S., Chernock R.D., HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: Utility of microscopic features in predicting patient outcome, Head and Neck Pathol, 3, 3, pp. 186-194, (2009)

[6]

El-Mofty S.K., Patil S., Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: Characterization of a distinct phenotype, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 101, 3, pp. 339-345, (2006)

[7]

Chernock R.D., Lewis J.S., Zhang Q., Et al., Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: A distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma, Hum Pathol, 41, 7, pp. 1016-1023, (2010)

[8]

Begum S., Westra W.H., Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status, Am J Surg Pathol, 32, 7, pp. 1044-1050, (2008)

[9]

Jo V.Y., Mills S.E., Stoler M.H., Et al., Papillary squamous cell carcinoma of the head and neck: Frequent association with human papillomavirus infection and invasive carcinoma, Am J Surg Pathol, 33, 11, pp. 1720-1724, (2009)

[10]

Singhi A.D., Stelow E.B., Mills S.E., Et al., Lymphoepithelial-like carcinoma of the oropharynx: A morphologic variant of HPV-related head and neck carcinoma, Am J Surg Pathol, 34, 6, pp. 800-805, (2010)

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