Aberrant p16 methylation, a possible epigenetic risk factor in familial esophageal squamous cell carcinoma

被引：30

作者：

Mohammad Reza Abbaszadegan

Hamid Reza Raziee

Kamran Ghafarzadegan

Mohammad Taghi Shakeri

Sima Afsharnezhad

Mohammad Reza Ghavamnasiry

机构：

[1] Mashhad University of Medical Sciences (MUMS),Division of Human Genetics, Immunology Research Center, Bu

[2] Omid Oncology Hospital,Ali Research Institute

[3] MUMS,Department of Radiation Oncology

[4] Omid Oncology Hospital,Department of Pathology

[5] MUMS,Department of Community Medicine

[6] Ghaem Hospital,Department of Biochemistry

[7] MUMS,Human Genetics Laboratory

[8] Medical School of Azad University,undefined

[9] Mashhad University of Medical Sciences,undefined

来源：

International Journal of Gastrointestinal Cancer | 2005年 / 36卷 / 1期

关键词：

Esophageal cancer; gene; methylation; familial; blood;

D O I：

10.1385/IJGC:36:1:047

中图分类号：

学科分类号：

摘要：

Aim. Detection of methylation in the p16 gene, an inhibitor of cyclin D-dependent protein kinase, as a new tumor marker for early detection of esophageal squamous cell carcinoma (ESCC) in DNA derived from blood and serum.

引用

页码：47 / 53

页数：6

共 40 条

[1]

Anker P(2003)Circulating nucleic acids in plasma and serum as a noninvasive investigation for cancer: time for large-scale clinical studies? Int J Cancer 103 149-152

[2]

Mulcahy H(1998)Cyclins-dependent kinases, cyclin-dependent kinase inhibitors and their role in head and neck cancer Clin Otolaryngol 23 420-424

[3]

Stroun M(2003)Gene silencing in cancer in association with promoter hypermethylation N Engl J Med 349 2042-2054

[4]

Jeannon JP(2001)DNA methylation, chromatin inheritance, and cancer Oncogene 20 3156-3165

[5]

Wilson JA(1998)Aberrant methylation of Proc Natl Acad Sci USA 95 11,891-11,896

[6]

Herman JG(1996) (INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis Proc Natl Acad Sci USA 93 9821-9826

[7]

Baylin Stephen B(2002)Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Cancer Res 62 4938-4944

[8]

Rountree MR(1997)Modes of silencing of Blood 89 2500-2506

[9]

Bachman KE(1999) in development of esophagel squamous cell carcinoma Cancer Res 59 71-73

[10]

Herman JG1(2000)Frequent hypermethylation of Cancer Res 60 892-895

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