Biochemical aspects and functional role of the copper-containing amine oxidases

被引：9

作者：

F. Buffoni

G. Ignesti

机构：

[1] Department of Pharmacology, University of Florence, Florence

来源：

InflammoPharmacology | 2003年 / 11卷 / 3期

关键词：

Amine oxidases; Copper; EC; 1.4.3.6;

D O I：

10.1163/156856003322315550

中图分类号：

学科分类号：

摘要：

The copper-containing amine oxidases of the class EC 1.4.3.6 share many biochemical similarities. They contain cupric copper and catalyse the same general reaction. In mammals, diamine oxidase has a role in the metabolism of histamine, some other diamines and spermine oxidase, involved in the metabolism of polyamines. However, the functional role of benzylamine oxidase (BAO) and the tissue semicarbazide-sensitive amine oxidases (SSAO) is still under investigation. Circulating BAO is derived from the tissue SSAO. It has a high affinity for benzylamine and its role in the extra-cellular matrix includes the maturation of pro-elastin and control of the inflammatory process.

引用

页码：203 / 209

页数：6

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