Effect of diet on vascular reactivity: an emerging marker for vascular risk.

被引:42
作者
West S.G. [1 ]
机构
[1] Department of Biobehavioral Health, Pennsylvania State University, 315 Health and Human Development Building East, University Park, 16802, PA
关键词
Nitric Oxide; Endothelial Function; Brachial Artery; Vascular Reactivity; Arterioscler Thromb Vasc Biol;
D O I
10.1007/s11883-001-0034-7
中图分类号
学科分类号
摘要
New technology for studying vascular activity in vivo has shown that the endothelium plays a critical role in the development of atherosclerosis. The healthy endothelium is a metabolically active tissue that exquisitely regulates vascular tone via release of the powerful vasodilator, nitric oxide. Endothelial integrity reduces cell adhesion, lipid deposition, and other early steps in atherogenesis. There is compelling evidence that endothelial function can be altered within hours of eating certain foods, further affirming the role of dietary factors in the prevention and progression of cardiovascular disease. This article reviews recent work on dietary factors (fatty acids, L-arginine, antioxidants, polyphenols, and folic acid) that alter vascular tone, and critically evaluates two noninvasive measures (flow-mediated dilation and total peripheral resistance) for use in dietary intervention trials.
引用
收藏
页码:446 / 455
页数:9
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  • [1] Vogel RA(1998)Cholesterol, cholesterol lowering, and endothelial function Prog Cardiovasc Dis 41 117-136
  • [2] Corretti MC(1980)The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Nature 288 373-376
  • [3] Gellman J(1996)Endothelial function as an end-point in interventional trials: concepts, methods and current data J Hypertens 14 S111-S119
  • [4] Furchgott RF(2000)Endothelial function as a therapeutic target in coronary artery disease Curr Atheroscler Rep 2 303-307
  • [5] Zawadzki JV(1994)Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction J Am Coll Cardiol 24 1468-1474
  • [6] Luscher TF(1999)Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes: the RECIFE (Reduction of cholesterol in ischemia and function of endothelium) trial Circulation 99 3227-3233
  • [7] Noll G(1999)Folic acid improves arterial endothelial function in adults with hyperhomocystinemia J Am Coll Cardiol 34 2002-2006
  • [8] Sharma N(2000)Testing for endothelial dysfunction Ann Med 32 293-304
  • [9] Andrews TC(1995)Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility Br Heart J 74 247-253
  • [10] Celermajer DS(2000)Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus Circulation 101 1773-1779