Association of HNPCC and endometrial cancers

被引：20

作者：

Banno K. ^{[1
]}

Susumu N. ^{[1
]}

Yanokura M. ^{[1
]}

Hirao T. ^{[1
]}

Iwata T. ^{[1
]}

Hirasawa A. ^{[1
]}

Aoki D. ^{[1
]}

Sugano K. ^{[2
]}

Nozawa S. ^{[1
]}

机构：

[1] Department of Obstetrics, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582

[2] Oncogene Res. U./Cancer Prev. Unit, Tochigi Cancer Ctr. Res. Institute, Utsunomiya

来源：

International Journal of Clinical Oncology | 2004年 / 9卷 / 4期

关键词：

Endometrial cancer; hMLH1; hMSH2; HNPCC; Revised Amsterdam Criteria;

D O I：

10.1007/s10147-004-0402-8

中图分类号：

学科分类号：

摘要：

Hereditary nonpolyposis colorectal cancer (HNPCC) is among the representative familial cancers that are autosomally dominant inherited disorders. Because endometrial cancers develop at high rates in women with HNPCC, it is suggested that some endometrial cancers are familial cancers that are induced by mutations of the DNA mismatch repair (MMR) genes, as in HNPCC. To understand the clinical pathology of familial endometrial cancers that are associated with HNPCC, we surveyed the family histories of 385 patients with endometrial cancer and found that 0.5% of endometrial cancers met the new diagnostic criteria of HNPCC. From molecular and biological analyses, we found microsatellite instability in 30.8% of endometrial cancers and germline mutations of MMR genes in 8.3%. These results suggest a close relationship of MMR gene mutations to the development of endometrial cancers. For a better understanding of the clinical pathology of HNPCC-associated familial endometrial cancers, it is critical for gynecologists to perform a large multicenter study, including detailed family histories.

引用

页码：262 / 269

页数：7

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