Non-alcoholic fatty liver disease is not associated with vitamin D deficiency in essential hypertension

被引：11

作者：

Catena C. ^{[1
]}

Cosma C. ^{[2
]}

Camozzi V. ^{[2
]}

Plebani M. ^{[2
]}

Ermani M. ^{[3
]}

Sechi L.A. ^{[1
]}

Fallo F. ^{[2
]}

机构：

[1] Department of Experimental and Clinical Medicine, University of Udine, Udine

[2] Department of Medicine, Clinica Medica 3, University of Padova, 35128 Padova

[3] Department of Neurosciences, University of Padova, Padova

来源：

High Blood Pressure & Cardiovascular Prevention | 2013年 / 20卷 / 1期

关键词：

Essential hypertension; NAFLD; Vitamin D;

D O I：

10.1007/s40292-013-0010-7

中图分类号：

学科分类号：

摘要：

An independent association between non-alcoholic fatty liver disease (NAFLD), a condition characterized by insulin-resistance, and low serum 25-hydroxyvitamin D [25(OH)D] levels has been reported. 25(OH)D concentrations are directly related with insulin sensitivity, whereas low [25(OH)D] predicts development of hypertension independent of glucose homeostasis alterations. We hypothesized that hypertensive patients with NAFLD have lower 25(OH)D than those without. Forty-four essential hypertensive (EH) patients with (n = 23) or without (n = 21) NAFLD were studied. No patient had diabetes mellitus, obesity, hyperlipidemia. The two hypertensive groups were compared with 24 healthy normotensive sex-, age-, body mass index (BMI)-matched subject, as controls. The two hypertensive groups had comparable age, sex, and blood pressure. BMI, glucose, insulin, homeostasis model assessment (HOMA) index and alanine aminotransferase were higher (P < 0.001 to <0.05) and plasma adiponectin was lower (P < 0.05) in EH patients with NAFLD than in those without NAFLD. Vitamin D deficiency, as defined by 25(OH)D levels <50 nmol/L, was similarly frequent in EH patients and controls (47.7 % vs. 45.8 %, P NS). Prevalence of hypovitaminosis D was not different in EH patients with and without NAFLD (37.5 % vs. 38.8 %, P NS). In patients with EH and no additional cardiometabolic risk factors NAFLD is not associated with vitamin D deficiency. © 2013 Springer International Publishing Switzerland.

引用

页码：33 / 37

页数：4

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