Prostatic intraepithelial neoplasia

被引：39

作者：

Bostwick D.G. ^{[1
]}

机构：

[1] Bostwick Laboratories, 6722 Patterson Avenue, Richmond, 23226, VA

来源：

Current Urology Reports | 2000年 / 1卷 / 1期

基金：

美国国家卫生研究院;

关键词：

Androgen Deprivation Therapy; Finasteride; Prostate Cancer; Prostatic Intraepithelial Neoplasia; Radical Prostatectomy;

D O I：

10.1007/s11934-000-0037-x

中图分类号：

学科分类号：

摘要：

High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely pre-invasive stage of adenocarcinoma, a decade after its first formal description. PIN has a high predictive value as a marker for adenocarcinoma, and its identification warrants repeat biopsy for concurrent or subsequent invasive carcinoma. The only method of detection is biopsy; PIN does not significantly elevate serum prostate-specific antigen concentration or its derivatives and cannot be detected by ultrasound. Most studies suggest that most patients with PIN will develop carcinoma within 10 years. PIN is associated with progressive abnormalities of phenotype and genotype that are similar to cancer rather than normal prostatic epithelium, indicating impairment of cell differentiation with advancing stages of prostatic carcinogenesis. Androgen deprivation therapy decreases the prevalence and extent of PIN, suggesting that this form of treatment may play a role in chemoprevention. © 2002, Current Science Inc.

引用

页码：65 / 70

页数：5

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