Metformin and gestational diabetes

被引：29

作者：

Charles J. Glueck

Naila Goldenberg

Patricia Streicher

Ping Wang

机构：

[1] Jewish Hospital Cholesterol Center, Cincinnati, OH 45229

来源：

Current Diabetes Reports | 2003年 / 3卷 / 4期

基金：

英国医学研究理事会;

关键词：

Insulin Resistance; Metformin; Preeclampsia; Gestational Diabetes Mellitus; Impaired Glucose Tolerance;

D O I：

10.1007/s11892-003-0022-0

中图分类号：

学科分类号：

摘要：

Pregnancy increases requirements for insulin secretion, increasing insulin resistance and demands on pancreatic β cells, promoting development of gestational diabetes (GD), particularly in women with preexisting insulin resistance, commonly in women with polycystic ovary syndrome. Preliminary studies suggest that metformin may have the unique potential to prevent the development of GD. We postulate that interventions that reduce insulin resistance and lower requirements for endogenous insulin secretion can preserve β-cell function and prevent the development of type 2 diabetes mellitus. Copyright © 2003 by Current Science Inc.

引用

页码：303 / 312

页数：9

共 75 条

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