Complex rhythmicity of growth hormone secretion in humans

被引：23

作者：

Surya S. ^{[1
]}

Symons K. ^{[1
]}

Rothman E. ^{[2
]}

Barkan A.L. ^{[1
]}

机构：

[1] Department of Internal Medicine, Division of MEND, University of Michigan Medical Center, Ann Arbor

[2] Department of Statistics, University of Michigan, Ann Arbor

来源：

Pituitary | 2006年 / 9卷 / 2期

关键词：

Growth hormone (GH); Hypothalamus; Pulsatility; Rhythm; Secretion;

D O I：

10.1007/s11102-006-9079-5

中图分类号：

学科分类号：

摘要：

To better characterize the 24 hr GH secretion pattern in humans, we studied frequently sampled 24 hr GH profiles in 93 young (18-45 years of age) healthy, fed volunteers: men (n = 67) and women (n = 26) with BMI<26kg/m2. Analysis of the composite GH series in men revealed 3 significant GH "waves" with peaks occurring at midnight (p < 0.0001), at noon (p < 0.02) and at 1800h (p < 0.0001). In women, similar pattern was seen, with three GH "waves" peaking at midnight (p < 0.0001), 1100h (p < 0.02) and at 1600h (p < 0.002). We conclude that the 24 hr rhythmicity of GH secretion is far more complex than currently appreciated. The attribution of the two daytime GH "waves" to food consumption is unlikely but cannot be excluded at the present time. The complex temporal pattern of pulsatile GH secretion may have important effects on regulation of target cell function. © Springer Science + Business Media, LLC 2006.

引用

页码：121 / 125

页数：4

共 42 条

[1]

Van Cauter E., Copinschi G., Interrelations between sleep and the somatotropic axis, Sleep, 21, pp. 553-563, (1998)

[2]

van Cauter E., Copinschi G., A Quantitative estimation of GH secretion in normal man: Reproducibility and relation to sleep and time of day, J Clin Endocrinol Metab, 74, pp. 1441-1450, (1992)

[3]

Barkan A.L., DeMott -Friberg R., Samuels M., GH secretion in Primary adrenal insufficiency: Effects of cortisol withdrawal and patterned replacement on GH pulsatility and circadian rhythmicity, Pituitary, 3, pp. 175-179, (2000)

[4]

Jaffe C.A., Barkan A.L., Regulatory mechanisms of GH secretion are sexually dimorphic, Clin Invest, 102, pp. 153-164, (1998)

[5]

Dimaraki E.V., Jaffe C.A., Bowers C.Y., Marbach P., Barkan A.L., Pulsatile and nocturnal growth hormone secretions in men do not require periodic declines of somatostatin, Am J Physiol (Endocrinol Metab), 285, (2003)

[6]

Dimaraki E.V., Jaffe C.A., Demott-Friberg R., Russell-Aulet M., Bowers C.Y., Marbach P., Barkan A.L., Generation of growth hormone pulsatility in women: Evidence against somatostatin withdrawal as pulse initiator, Am J Physiol Endocrinol Metab, 280, (2001)

[7]

Jaffe C.A., Turgeon D.K., DeMott Friberg R., Watkins P.R., Barkan A.L., Nocturnal augmentation of GH secretion is preserved during repetitive bolus administration of GHRH: Potential involvement of endogenous somatostatin, J Clin Endocrinol Metab, 80, pp. 3321-3326, (1995)

[8]

Obal Jr. F., Krueger J.M., GHRH and sleep, Sleep Med Rev, 8, pp. 367-377, (2004)

[9]

Avram A., Jaffe C.A., Symons K.V., Barkan A.L., Endogenous circulating ghrelin does not mediate GH rhythmicity or response to fasting, J Clin Endocrinol Metab, 90, pp. 2982-2987, (2005)

[10]

Van Cauter E., Plat L., Physiology of GH secretion during sleep, J Ped, 128, (1996)

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