Low birth weight and longitudinal trends of cardiovascular risk factor variables from childhood to adolescence: The bogalusa heart study

被引：27

作者：

Frontini M.G. ^{[1
]}

Srinivasan S.R. ^{[2
]}

Xu J. ^{[2
]}

Berenson G.S. ^{[2
]}

机构：

[1] Department of Public Health, Eastern Virginia Medical School, Norfolk, VA 23507-1980

[2] Tulane Ctr. for Cardiovasc. Health, Department of Epidemiology, Tulane Univ. Health Services Center, New Orleans, LA

来源：

BMC Pediatrics | / 4卷 / 1期

关键词：

Birth Weight; Longitudinal Trend; Bogalusa Heart Study; Early Risk Factor; Risk Factor Variable;

D O I：

10.1186/1471-2431-4-22

中图分类号：

学科分类号：

摘要：

Background: Several studies have linked low birth weight to adverse levels of cardiovascular risk factors and related diseases. However, information is sparse at a community level in the U.S. general population regarding the effects of low birth weight on the longitudinal trends in cardiovascular risk factor variables measured concurrently from childhood to adolescence. Methods: Longitudinal analysis was performed retrospectively on data collected from the Bogalusa Heart Study cohort (n = 1141; 57% white, 43% black) followed from childhood to adolescence by repeated surveys between 1973 and 1996. Subjects were categorized into low birth weight (below the race-specific 10th percentile; n = 123) and control (between race-specific 50-75th percentile; n = 296) groups. Results: Low birth weight group vs control group had lower mean HDL cholesterol (p = 0.05) and higher LDL cholesterol (p = 0.05) during childhood (ages 4-11 years); higher glucose (p = 0.02) during adolescence. Yearly rates of change from childhood to adolescence in systolic blood pressure (p = 0.02), LDL cholesterol (p = 0.05), and glucose (p = 0.07) were faster, and body mass index (p = 0.03) slower among the low birth weight group. In a multivariate analysis, low birth weight was related independently and adversely to longitudinal trends in systolic blood pressure (p = 0.004), triglycerides (p = 0.03), and glucose (p = 0.07), regardless of race or gender. These adverse associations became amplified with age. Conclusions: Low birth weight is characterized by adverse developmental trends in metabolic and hemodynamic variables during childhood and adolescence; and thus, it may be an early risk factor in this regard. © 2004 Frontini et al; licensee BioMed Central Ltd.

引用

页数：7

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