The structure of a cypovirus and the functional organization of dsRNA viruses

被引：116

作者：

Hill C.L. ^{[1
]}

Booth T.F. ^{[1
]}

Prasad B.V.V. ^{[1
]}

Grimes J.M. ^{[1
]}

Mertens P.P.C. ^{[1
]}

Sutton G.C. ^{[1
]}

Stuart D.I. ^{[1
]}

机构：

[1] Laboratory of Molecular Biophysics, Rex Richards Building, Oxford OX1 3QU, South Parks Road

来源：

Nature Structural Biology | 1999年 / 6卷 / 6期

基金：

美国国家卫生研究院; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1038/9347

中图分类号：

学科分类号：

摘要：

Cytoplasmic polyhedrosis virus (CPV) is unique among the double-stranded RNA viruses of the family Reoviridae in having a single capsid layer. Analysis by cryo-electron microscopy allows comparison of the single shelled CPV and orthoreovirus with the high resolution crystal structure of the inner shell of the bluetongue virus (BTV) core. This suggests that the novel arrangement identified in BTV, of 120 protein subunits in a so-called 'T=2' organization, is a characteristic of the Reoviridae and allows us to delineate structural similarities and differences between two subgroups of the family - the turreted and the smooth-core viruses. This in turn suggests a coherent picture of the structural organization of many dsRNA viruses.

引用

页码：565 / 568

页数：3

共 69 条

[1]

Miura K(1969)undefined J. Invertebrate pathology 14 262-479

[2]

Fujii-Kawata I(1980)undefined Virology 105 467-1041

[3]

Iwata H(1993)undefined J.Cell Biol. 122 1023-46

[4]

Kawase S(1998)undefined Virology 245 33-275

[5]

Yazaki K(1988)undefined J. Mol. Biol. 199 269-200

[6]

Miura K(1997)undefined Virology 235 191-2142

[7]

Dryden KA(1992)undefined J.Virol. 66 2135-69

[8]

Dryden KA(1992)undefined J. Struct. Biol. 109 61-967

[9]

Prasad BVV(1996)undefined Structure 4 957-8549

[10]

Wang GJ(1998)undefined J.Virol. 72 8541-388

← 1 2 3 4 5 6 7 →