The effectiveness of trastuzumab (Herceptin) combined with chemotherapy for gastric carcinoma with overexpression of the c-erbB-2 protein

被引：70

作者：

Rebischung C. ^{[1
]}

Barnoud R. ^{[2
]}

Stéfani L. ^{[1
]}

Faucheron J.-L. ^{[3
]}

Mousseau M. ^{[1
]}

机构：

[1] Department of Oncology and Haematology, University Hospital, 38043 Grenoble Cedex 9

[2] Department of Anatomopathology, University Hospital of Grenoble, Grenoble

[3] Department of Surgery, University of Grenoble, Grenoble

来源：

Gastric Cancer | 2005年 / 8卷 / 4期

关键词：

Anti-EGF antibody; c-erbB-2; protein; Gastric cancer; Trastuzumab;

D O I：

10.1007/s10120-005-0342-7

中图分类号：

学科分类号：

摘要：

The c-erbB-2 protein is overexpressed in 7% of gastric cancer cases, suggesting that anti-c-erbB-2 antibody therapy (trastuzumab; Herceptin) could be used. We report here a 28-year-old woman with metastatic gastric cancer overexpressing c-erbB-2 (3 + strong membrane staining on immunohistochemistry) who was treated with trastuzumab in combination with chemotherapy. A complete response was obtained with a combination of trastuzumab and oxaliplatin and was maintained with trastuzumab alone for 18 months. The patient relapsed and chemotherapy (capecitabine, docetaxel) was combined with the anti-c-erbB-2 antibody. The patient survived for 4 years with metastatic disease controlled for 2 years by immunochemotherapy. We conclude that the combination of trastuzumab and chemotherapy is efficient in the treatment of metastatic gastric carcinoma with overexpression of the c-erbB-2 protein. © 2005 by International and Japanese Gastric Cancer Associations.

引用

页码：249 / 252

页数：3

共 14 条

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