Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole: An increasing problem

被引:71
作者
Al-Jasser A.M. [1 ]
机构
[1] King Saud University Fellowship of Pathology (Microbiology), Department of Microbiology, Armed Forces Hospital
关键词
Chronic Myeloid Leukemia; Moxifloxacin; Colistin; Gatifloxacin; Ticarcillin;
D O I
10.1186/1476-0711-5-23
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学科分类号
摘要
Stenotrophomonas maltophilia (S. maltophilia) has recently emerged as an important nosocomial pathogen. Treatment of invasive infections caused by this organism is difficult as the bacterium is frequently resistant to a wide range of commonly used antimicrobials. Trimethoprimsulfamethoxazole (TMP - SXT) is recommended as the agent of choice for the treatment of S. maltophilia infections. However, the development of resistance to this antibiotic represents a real challenge to laboratorians and clinicians. This letter describes the first isolation of S. maltophilia resistant to TMP - SXT from two patients treated at Riyadh Armed Forces Hospital which is a major tertiary hospital in Saudi Arabia. © 2006 Al-Jasser; licensee BioMed Central Ltd.
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共 17 条
[1]  
Lennett E.H., Baburs A., Hausler W.J., Shadomy H.J., Manual of Clinical Microbiology
[2]  
Koseoglu O., Sener B., Gulmez D., Altun B., Gur D., Stenotrophomonas maltophilia as a nosocomial pathogen, New Microbiol, 27, pp. 273-279, (2004)
[3]  
Denton M., Kerr K.G., Microbiological and clinical aspects of infection associated with Stenotrophomonas maltophilia, Clin Microbiol Rev, 11, pp. 57-80, (1998)
[4]  
Micozzi A., Venditti M., Monaco M., Friedrich A., Taglietti F., Santilli S., Martino P., Bacteremia due to Stenotrophomonas maltophilia in patients with hematological malignancies, Clin Infect Dis, 31, pp. 705-711, (2000)
[5]  
Tsiodras S., Pittet D., Carmeli Y., Eliopoulos G., Boucher H., Harbath S., Clinical implications of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole: A study of 69 patients at 2 university hospitals, Scand J Infect Dis, 32, pp. 651-656, (2000)
[6]  
Smit W.J., Boquest A.L., Geddes J.E., Tosolini F.A., The antibiotic susceptibilities of Xanthomonas maltophilia and their relation to clinical management, Pathology, 26, pp. 321-324, (1994)
[7]  
Vartivarian S., Anaissie E., Bodey G., Sprigg H., Rolston K., A changing pattern of susceptibility of Xanthomonas maltophilia
[8]  
Implications for therapy, Antimicrob Agents Chemother, 38, pp. 624-627, (1994)
[9]  
Performance Standards for Antimicrobial Susceptibility Testing 15th Informational Supplement (M 100-S15), (2005)
[10]  
Pankuch G.A., Jacobs M.R., Rittenhouse S.F., Appelbaum P.C., Susceptibilities of 123 strains of Xanthomonas moltophilia to eight Blactams (including B-lactam-B-lactamase inhibitor combinations) and ciprofloxacin tested by five methods, Antimicrob Agents Chemother, 38, pp. 2317-2322, (1994)