Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models

被引：17

作者：

Kyoung K.S. ^{[1
]}

Rhee H.I. ^{[2
]}

Park E.K. ^{[1
]}

Jung K. ^{[2
]}

Jeon H.J. ^{[2
]}

Kim J.-H. ^{[2
]}

Yoo H. ^{[2
]}

Han C.-K. ^{[3
]}

Cho Y.-B. ^{[4
]}

Ryu C.J. ^{[5
]}

Yang H.I. ^{[6
]}

Yoo M.C. ^{[7
]}

机构：

[1] East-West Bone and Joint Research Center, Kyung Hee University Neo Medical Hospital, Seoul 134-090, 149 Sangil-dong, Gangdong-gu

[2] Life Science Research Center, SK Chemicals, Suwon-Si, Kyoungki-Do 440-745, 600 Jungja-1-dong, Changan-Ku

[3] Central R and D, Ahngook Pharm., Suwon-Si, Kyoungki-Do, Iui-Dong, Yeongtong-gu

[4] Central Research Institute, Whan In Pharm., Co., Ltd., Suwon-Si, Kyoungki-Do, Iui-Dong, Yeongtong-gu

[5] Department of Bioscience and Biotechnology, Sejong University

[6] Department of Internal Medicine, Kyung Hee University Neo Medical Hospital, Seoul 134-090, 149 Sangil-dong, Gangdong-gu

[7] Department of Orthopedic Surgery, Kyung Hee University Neo Medical Hospital, Seoul 134-090, 149 Sangil-dong, Gangdong-gu

来源：

Chinese Medicine | / 3卷 / 1期

关键词：

Nitric Oxide; Celecoxib; Peritoneal Macrophage; Berberine; Hesperidin;

D O I：

10.1186/1749-8546-3-10

中图分类号：

学科分类号：

摘要：

Background: KHU14, an ethanolic extract of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) was tested for its anti-inflammatory effects. Methods: Three out of 20 herbs were found to have anti-inflammatory effects. The formulation of these herbs, i.e. KHU14 was tested for croton oil-induced ear edema, carrageenan-induced paw edema, acetic acid-induced capillary permeability, cotton pellet and delayed type hypersensitivity. Results: KHU14 exhibited anti-inflammatory effects in animal models of acute and chronic inflammation. The anti-inflammatory activity of KHU14 observed was comparable to that of celecoxib. KHU14 inhibited the production of NO and PGE2 in LPS/IFN-gamma-stimulated peritoneal macrophages, and reduced edema and the amount of infiltrated cells in animal models. Conclusion: KHU14 exhibited anti-inflammatory effects as demonstrated in typical immunological tests for anti-inflammation in vitro and in vivo. © 2008 Kim et al; licensee BioMed Central Ltd.

引用

共 23 条

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