Possible role of the cavernous sinus veins in cerebrospinal fluid absorption

被引：34

作者：

Johnston M. ^{[1
]}

Armstrong D. ^{[1
]}

Koh L. ^{[1
]}

机构：

[1] Neuroscience Program, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M4N 3M5

来源：

Cerebrospinal Fluid Research | / 4卷 / 1期

关键词：

Internal Carotid Artery; Lymphatic Vessel; Cavernous Sinus; Subarachnoid Space; Superior Sagittal Sinus;

D O I：

10.1186/1743-8454-4-3

中图分类号：

学科分类号：

摘要：

The purpose of this investigation was to enhance our understanding of cerebrospinal fluid (CSF) absorption pathways. To achieve this, Microfil (a coloured silastic material) was infused into the subarachnoid space (cisterna magna) of sheep post mortem, and the relevant tissues examined macroscopically and microscopically. The Microfil was taken up by an extensive network of extracranial lymphatic vessels in the olfactory turbinates. In addition however, Microfil also passed consistently through the dura at the base of the brain. Microfil was noted in the spaces surrounding the venous network that comprises the cavernous sinus, in the adventitia of the internal carotid arteries and adjacent to the pituitary gland. Additionally, Microfil was observed within the endoneurial spaces of the trigeminal nerve and in lymphatic vessels emerging from the epineurium of the nerve. These results suggest several unconventional pathways by which CSF may be removed from the subarachnoid space. The movement of CSF to locations external to the cranium via these routes may lead to its absorption into veins and lymphatics outside of the skull. The physiological importance of these pathways requires further investigation. © 2007 Johnston et al; licensee BioMed Central Ltd.

引用

共 26 条

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