Lipids and diabetic renal disease

被引：46

作者：

Cooper M.E. ^{[1
]}

Jandeleit-Dahm K.A.M. ^{[1
]}

机构：

[1] JDRF Danielle Alberti Memorial Centre for Diabetic Complications, Vascular Division - Wynn Domain, Baker Heart Research Institute, Melbourne, Vic. 3004

来源：

Current Diabetes Reports | 2005年 / 5卷 / 6期

关键词：

Diabetic Nephropathy; Atorvastatin; Pravastatin; Lovastatin; Renal Injury;

D O I：

10.1007/s11892-005-0053-9

中图分类号：

学科分类号：

摘要：

Diabetic nephropathy is commonly associated with dyslipidemia, but the role of lipids in the progression of this disorder remains unresolved. In particular, the role of lipid-lowering drugs, such as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and fibrates, as renoprotective agents is not clarified. Experimental studies have demonstrated that dietary lipids promote renal injury and that statins, independent of their lipid-lowering effects, confer renoprotection via effects on intrarenal hemodynamics and renal cytokine and chemokine expression. Clinical studies have in general been underpowered, but a recent meta-analysis and findings from the Heart Protection Study suggest that statins may be renoprotective. Nevertheless, with the convincing antiatherosclerotic effects of these agents, including in the setting of diabetes, they should be widely administered in the diabetic population with or at risk for nephropathy. Copyright © 2005 by Current Science Inc.

引用

页码：445 / 448

页数：3

共 45 条

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