Effect of Gabapentin on morphine demand and pain after laparoscopic sterilization using Filshie clips. A double blind randomized clinical trial

被引：21

作者：

Bartholdy J. ^{[1
]}

Hilsted K.L. ^{[2
]}

Hjortsoe N.C. ^{[3
]}

Engbaek J. ^{[1
]}

Dahl J.B. ^{[2
]}

机构：

[1] Department of Day Surgery, Copenhagen University Hospital Herlev, 2730 Herlev

[2] Department of Anaesthesiology, Copenhagen University Hospital Glostrup, 2600 Glostrup

[3] Department of Day Surgery, Copenhagen University Hospital Glostrup, 2600 Glostrup

来源：

BMC Anesthesiology | / 6卷 / 1期

关键词：

Morphine; Gabapentin; Remifentanil; Lornoxicam; Morphine Consumption;

D O I：

10.1186/1471-2253-6-12

中图分类号：

学科分类号：

摘要：

Background: A considerable number of patients require opioids during recovery after laparoscopic sterilization. This implies nausea, dizziness and sedation and increases the number of unplanned admissions. Gabapentin has shown excellent postoperative analgesic effect in a number of recent studies with few side effects. This study was designed to test whether gabapentin given preoperatively can reduce the number of patients needing morphine in the recovery period. Methods: 80 females scheduled for laparoscopic sterilization using Filshie clips were randomized to two treatment groups (Gaba group and control group). All patients received lornoxicam 8 mg p.o. 30 min. before the procedure. Patients in the Gaba group received gabapentin 1200 mg p.o. and patients in the control group received placebo capsules prior to the procedure. All patients were anesthetized according to a protocol, using remifentanil and propofol. Postoperative analgesia was obtained with patient controlled infusion of morphine. Pain, nausea, dizziness and sedation were scored at 2 and 4 hours after end of anesthesia. The expenditure of morphine was the primary measure for the effect of analgesia and the number of patients demanding morphine was the primary endpoint. Results: Three patients were excluded because of procedural errors and one because of conversion to open surgery. 38 patients completed the study in each group. 32 (84%) patients in the gabapentin group and 37 (97%) patients in the control group did require morphine in the recovery period. (p = 0,049). There was no significant difference between mean morphine consumption, pain scores and frequency of adverse effects (nausea, dizziness, sedation and vomiting) Conclusion: The postoperative analgesic effect of gabapentin given preoperatively was confirmed in this study. For this procedure, with pain predominantly in the immediate recovery period, and of less intensity than after major surgical procedures, the effect demonstrated is much less pronounced than in similar studies of major surgery. General use of gabapentin as analgesic for laparoscopic sterilization is not supported by this study. © 2006 Bartholdy et al; licensee BioMed Central Ltd.

引用

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