Confirmatory studies on the antioxidant and antidiabetic effect of quercetin in rats

被引：87

作者：

Abdelmoaty M.A. ^{[1
,3
]}

Ibrahim M.A. ^{[2
,4
]}

Ahmed N.S. ^{[1
,3
]}

Abdelaziz M.A. ^{[1
,3
,4
]}

机构：

[1] Department of Biochemistry, Sohag Faculty of Medicine, Sohag University, Sohag

[2] Department of Pharmaceutics, Sohag University, Sohag

[3] Sohag Faculty of Medicine, Sohag University, Sohag

[4] El-Azhar Faculty of Pharmacy, Elazhar University (Assiut), Sohag

来源：

Indian Journal of Clinical Biochemistry | 2010年 / 25卷 / 2期

关键词：

Antidiabetic; Antioxidant; Flavonoid; Quercetin;

D O I：

10.1007/s12291-010-0034-x

中图分类号：

学科分类号：

摘要：

Quercetin (QE), one of natural flavanoid group, was widely distributed as a secondary metabolite in plant kingdom. It has been believed that oxidative stress plays a role in the pathogenesis of diabetes mellitus (DM). The aim of the present study was the evaluation of possible effects of QE on blood glucose and antioxidant enzymes in experimental streptozotocin (STZ)-induced diabetes in rats. STZ was injected intraperitoneally with single dose of 50 mg/kg for diabetes induction. QE (15 mg/kg bw day, intraperitoneal (i.p.) injection) was injected for 3 days prior to STZ administration; these injections were continued to the end of the study (for 25 days). Glucose tolerance test and random plasma glucose were done for all animals. Cellular antioxidant enzymes such as glutathione peroxidase (GSHPx), superoxide dismutase (SOD) and catalase (CAT) activities were measured in pancreatic homogenates. Quercetin had no effect on plasma glucose level of normal animals but its pre- treatment was able to prevent diabetes induced by single intraperitoneal injection of streptozocintreated rats. Antioxidant enzyme activity significantly decreased in STZ induced diabetic group. QE treatment significantly increased the antioxidant enzyme activities. It could be concluded that quercetin, a flavonoid with antioxidant properties, exerting its beneficial antidiabetic effects. © 2010 Association of Clinical Biochemists of India.

引用

页码：188 / 192

页数：4

共 25 条

[1]

Baynes J., Thorpe S., The role of oxidative stress in diabetic complications, Curr Opin Endocrinol, 3, pp. 277-284, (1996)

[2]

Ihara Y., Toyokuni S., Uchida K., Odaka H., Tanaka T., Ikeda H., Hyperglycemia causes oxidative stress in pancreatic beta cells of GK rats a model of type 2 diabetes, Diabetes, 48, pp. 927-932, (1999)

[3]

Kanter M., Meral I., Dede S., Gunduz H., Cemek M., Ozbek H., Effects of Nigella sativa L. and Urtica dioica L. on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in CCl 4-treated rats, J Vet Med A Physiol Pathol Clin Med, 50, pp. 264-268, (2003)

[4]

Bray T.M., Bettger W.J., The physiological role of zinc as an antioxidant, Free Radical Biology and Medicine, 8, 3, pp. 281-291, (1990)

[5]

Rizk A., Hammouda F., Rimpler H., Kamel A., Iridoids and flavonoids of Teucrium polium herb, Planta Med, 2, pp. 87-88, (1986)

[6]

Middleton J., Effect of plant flavonoids on immune and inflammatory cell function, Adv Exp Med Biol, 439, pp. 175-182, (1998)

[7]

Laughton M., Evans P., Moroney M., Hoult J., Halliwell B., Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives, Relationship to Antioxidant Activity and to Iron Ion-reducing Ability Biochem Pharmacol, 42, pp. 1673-1681, (1991)

[8]

Boge G., Roche H., Balocco C., Amino acid transport by intestinal brush border vesicles of a marine fish, Boops salpa, Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 131, 1, pp. 19-26, (2002)

[9]

Du Thie G., Crozier A., Plant derived phenolic antioxidants, Curr Opin Clin Nutr Metab, 3, pp. 447-451, (2000)

[10]

Fuhrman B., Aviram M., Flavonoids protect LDL from oxidation and attenuate atherosclerosis, Current Opinion in Lipidology, 12, 1, pp. 41-48, (2001)

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