In vivo estimation of water content in cerebral white matter of brain tumour patients and normal individuals: Towards a quantitative brain oedema definition

被引：23

作者：

Andersen C. ^{[1
,2
]}

机构：

[1] Department of Neurosurgery, Skejby Hospital, Aarhus University Hospital

[2] Department of Neurosurgery, Ålborg Hospital

来源：

Acta Neurochirurgica | 1997年 / 139卷 / 3期

关键词：

Brain oedema; Brain tumour; T1; T2; While matter;

D O I：

10.1007/BF01844760

中图分类号：

学科分类号：

摘要：

The 'building stones' in MR imaging, namely the relaxation times (RT) correlate in certain circumstances well with water content of cerebral white matter (WM). It is, therefore, possible to estimate regional in vivo water content using RT imaging with an accuracy within ± 2-4%. The purpose of the present prospective investigation was to study the RT's of cerebral WM and thereby estimate normal in vivo water content. Furthermore, the method was used to study whether water content was different in the apparently normal cerebral hemisphere of brain tumour patients compared to normal individuals. RT data of the non-tumour bearing hemisphere in 42 brain tumour patients were compared to 35 normal individuals. Results: 1) Water content was significantly higher in the posterior WM as compared to frontal WM in both normal individuals and apparently normal WM in brain tumour patients and this appears to be a true physiological difference. 2) Water content of normal WM correlated positively with age. 3) There was no significant difference between RT data from the normal hemisphere in histologically different types of brain tumours. 4) Water content was significantly higher in the apparently normal WM of brain tumour patients compared to normal individuals. 5) Based on the present results, a definite lower threshold of white matter oedema could be established as 75% water content, corresponding to a T1 of 0.850 seconds.

引用

页码：249 / 256

页数：7

共 25 条

[1]

Adachi M., Feigin I., Cerebral oedema and the water content of normal white matter, J Neurol Neurosurg Psychiatry, 29, pp. 446-450, (1966)

[2]

Adachi M., Rosenblum W.I., Feigin I., Hypertensive disease and cerebral oedema, J Neurol Neurosurg Psychiatry, 29, pp. 451-455, (1966)

[3]

Agartz I., Saaf J., Wahlund L., Wetterberg L., T1 and T2 relaxation time estimates in the normal human brain, Radiology, 181, pp. 537-543, (1991)

[4]

Andersen C., Astrup J., Gyldensted C., Quantitative MR analysis of glucocorticoid effects on peritumoral edema associated with intracranial meningiomas and metastases, J Comp Assist Tomogr, 18, pp. 509-518, (1994)

[5]

Andersen C., Haselgrove J.C., Doenstrup S., Astrup J., Gyldensted C., Resorption of peritumoral edema in cerebral gliomas during dexamethasone treatment evaluated by NMR relaxation time imaging, Acta Neurochir, 122, pp. 218-224, (1993)

[6]

Andersen C., Taagehoj Jensen F., Precision, accuracy and image plane uniformity in NMR relaxation time imaging on a 1.5T whole-body MR imaging system, Magn Reson Imaging, 12, 4, pp. 775-784, (1994)

[7]

Beaney R.P., Brooks D.J., Leenders K.L., Thomas D.G.T., Jones T., Halnan K.E., Blood flow and oxygen utilisation in the contralateral cerebral cortex of patients with untreated intracranial tumours as studied by positron emission tomography, with observations on the effect of decompressive surgery, J Neurol Neurosurg Psychiatry, 48, pp. 310-319, (1985)

[8]

Bell B.A., Kean D.M., MacDonald H.L., Barnett G.H., Douglass R.H.B., Smith M.A., McGhee C.N.J., Miller J.D., Tocher J.L., Best J.J.K., Brain water measured by magnetic resonance imaging, Lancet, 329, pp. 66-69, (1987)

[9]

Bottomley P.A., Foster T.H., Argersinger R.E., Pfeifer L.M., A review of normal tissue hydrogen NMR relaxation times mechanisms from 1-100 MHz: Dependence on tissue type, NMR frequency, temperature, species, excision, and age, Med Phys, 11, pp. 1-34, (1984)

[10]

Bottomley P.A., Hardy C.J., Argersinger R.E., Allen-Moore G., A review of 1H magnetic resonance relaxation in pathology: Are T1 and T2 diagnostic?, Med Phys, 14, pp. 1-37, (1987)

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