The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea

被引：124

作者：

Hassaballa H.A. ^{[1
,2
]}

Tulaimat A. ^{[3
,4
]}

Herdegen J.J. ^{[1
]}

Mokhlesi B. ^{[2
,3
]}

机构：

[1] Section of Pulmonary/Critical Care Medicine, Rush University Medical Center, Chicago, IL

[2] Rush Sleep Disorders Service and Research Center, Chicago, IL

[3] Division of Pulmonary and Critical Care Medicine, Cook County Hospital, Chicago, IL

[4] Division of Pulmonary and Critical Care Medicine, Chicago, IL 60612

来源：

Sleep and Breathing | 2005年 / 9卷 / 4期

关键词：

Continuous positive airway pressure; Glucose intolerance; Glycosylated hemoglobin; Obstructive sleep apnea;

D O I：

10.1007/s11325-005-0033-y

中图分类号：

学科分类号：

摘要：

Obstructive sleep apnea (OSA) is independently associated with glucose intolerance and insulin resistance, and recent studies have shown that continuous positive airway pressure (CPAP) improves insulin sensitivity. The objective of this study was to describe the change in glycosylated hemoglobin (HbA1c) after treatment with CPAP in patients with type 2 diabetes mellitus and OSA. To test this hypothesis, we performed a retrospective analysis of 38 patients seen in the sleep clinic of an urban public teaching hospital. All patients had OSA and type 2 diabetes mellitus, and their diabetic medication regimen had remained unchanged during the period of CPAP therapy. Sixty-one percent were men, body mass index was 42±9.5 kg/m2, and the Apnea-Hypopnea Index was 53±36 per hour. HbA1c before therapy with CPAP was 7.8±1.4% and decreased to 7.3±1.3% after 134±119 days of therapy (p<0.001). Treatment with CPAP leads to a clinically significant drop in HbA1c in patients with type 2 diabetes mellitus and severe OSA. © Springer-Verlag 2005.

引用

页码：176 / 180

页数：4

共 24 条

[1]

Grunstein R., Wilcox I., Yang T.S., Gould Y., Hedner J., Snoring and sleep apnoea in men: Association with central obesity and hypertension, Int J Obes Relat Metab Disord, 17, pp. 533-540, (1993)

[2]

Jennum P., Schultz-Larsen K., Christensen N., Snoring, sympathetic activity and cardiovascular risk factors in a 70 year old population, Eur J Epidemiol, 9, pp. 477-482, (1993)

[3]

Tiihonen M., Partinen M., Narvanen S., The severity of obstructive sleep apnoea is associated with insulin resistance, J Sleep Res, 2, pp. 56-61, (1993)

[4]

Elmasry A., Janson C., Lindberg E., Et al., The role of habitual snoring and obesity in the development of diabetes: A 10-year follow-up study in a male population, J Intern Med, 248, pp. 13-20, (2000)

[5]

Vgontzas A.N., Papanicolaou D.A., Bixler E.O., Et al., Sleep apnea and daytime sleepiness and fatigue: Relation to visceral obesity, insulin resistance, and hypercytokinemia, J Clin Endocrinol Metab, 85, pp. 1151-1158, (2000)

[6]

Elmasry A., Lindberg E., Berne C., Et al., Sleep-disordered breathing and glucose metabolism in hypertensive men: A population-based study, J Intern Med, 249, pp. 153-161, (2001)

[7]

Al-Delaimy W.K., Manson J.E., Willett W.C., Stampfer M.J., Hu F.B., Snoring as a risk factor for type II diabetes mellitus: A prospective study, Am J Epidemiol, 155, pp. 387-393, (2002)

[8]

Manzella D., Parillo M., Razzino T., Et al., Soluble leptin receptor and insulin resistance as determinant of sleep apnea, Int J Obes Relat Metab Disord, 26, pp. 370-375, (2002)

[9]

Punjabi N.M., Shahar E., Redline S., Et al., Sleep-disordered breathing, glucose intolerance, and insulin resistance: The sleep heart health study, Am J Epidemiol, 160, pp. 521-530, (2004)

[10]

Punjabi N.M., Sorkin J.D., Katzel L.I., Et al., Sleep-disordered breathing and insulin resistance in middle-aged and overweight men, Am J Respir Crit Care Med, 165, pp. 677-682, (2002)

← 1 2 3 →