Central sensitization fibromyalgia and other musculoskeletal disorders

被引：155

作者：

Lars Arendt-Nielsen

Thomas Graven-Nielsen

机构：

[1] Lab. for Human Exp. Pain Research, Center for Sensory-Motor Interaction, Aalborg University, DK-9220 Aalborg

来源：

Current Pain and Headache Reports | 2003年 / 7卷 / 5期

关键词：

Fibromyalgia; Hypertonic Saline; Central Sensitization; Tibialis Anterior Muscle; Dorsal Horn Neuron;

D O I：

10.1007/s11916-003-0034-0

中图分类号：

学科分类号：

摘要：

Muscle hyperalgesia and referred pain play an important role in chronic musculoskeletal pain. New knowledge on the involved basic mechanisms and better methods to assess muscle pain in the clinic are needed to revise and optimize treatment regimens. Increased muscle sensitivity is manifested as pain evoked by a normally non-nociceptive stimulus (allodynia), increased pain intensity evoked by nociceptive stimuli (hyperalgesia), or increased referred pain areas with associated somatosensory changes. Some manifestations of sensitization, such as expanded referred muscle pain areas in patients with chronic musculoskeletal pain, can be explained from animal experiments showing extrasegmental spread of sensitization. An important part of the pain manifestations (eg, tenderness and referred pain) related to chronic musculoskeletal disorders may result from peripheral and central sensitization, which may play a role in the transition from acute to chronic pain. Copyright © 2003 by Current Science Inc.

引用

页码：355 / 361

页数：6

共 83 条

[1]

Kellgren J.H., Observation on referred pain arising from muscle, Clin. Sci., 3, pp. 175-190, (1938)

[2]

Mense S., Referral of muscle pain, APS J., 3, pp. 1-9, (1994)

[3]

Marchettini P., Simone D.A., Caputi G., Ochoa J.L., Pain from excitation of identified muscle nociceptors in humans, Brain Res., 740, pp. 109-116, (1996)

[4]

Simone D.A., Marchettini P., Caputi G., Ochoa J.L., Identification of muscle afferents subserving sensation of deep pain in humans, J. Neurophysiol., 72, pp. 883-889, (1994)

[5]

Bendtsen L., Jensen R., Olesen J., Qualitatively altered nociception in chronic myofascial pain, Pain, 65, pp. 259-264, (1996)

[6]

Kosek E., Ekholm J., Hansson P., Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls, Pain, 64, pp. 415-423, (1996)

[7]

Lautenbacher S., Rollman G.B., McCain G.A., Multi-method assessment of experimental and clinical pain in patients with fibromyalgia, Pain, 59, pp. 45-53, (1994)

[8]

Norregaard J., Bendtsen L., Lykkegaard J., Jensen R., Pressure and heat pain thresholds and tolerances in patients with fibromyalgia, J. Musculoskel. Pain, 5, pp. 43-53, (1997)

[9]

Sorensen J., Bengtsson A., Ahlner J., Et al., Fibromyalgia: Are there different mechanisms in the processing of pain? A double-blind crossover comparison of analgesic drugs, J. Rheumatol., 24, pp. 1615-1621, (1997)

[10]

Svensson P., Arendt-Nielsen L., Nielsen H., Larsen J.K., Effect of chronic and experimental jaw muscle pain on pain-pressure thresholds and stimulus-response curves, J. Orofac. Pain, 9, pp. 347-356, (1995)

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