Antioxidant activities of isoflavones from the rhizomes ofbelamcanda chinensis on carbon tetrachloride-lnduced hepatic injury in rats

被引：17

作者：

Sang Hoon Jung

Yeon Sil Lee

Soon Sung Lim

Sanghyun Lee

Kuk Hyun Shin

Yeong Shik Kim

机构：

[1] Seoul National University,Natural Products Research Institute, College of Pharmacy

[2] Korea Institute of Science and Technology,Natural Products Research Center

[3] Seokwon Life Science Research Institute,Silver Biotechnology Research Center

[4] Hallym University,Natural Products Research Institute

[5] Seoul National University,undefined

来源：

Archives of Pharmacal Research | 2004年 / 27卷

关键词：

Belamcanda chinensis; Iridaceae; Tectorigenin; Tectoridin; Carbon tetrachloride; Antioxidant activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The present study was carried out to clarify whether tectorigenin and tectoridin isolated from the rhizomes ofBelamcanda chinensis (Iridaceae) inhibit hepatic damage induced by carbon tetrachloride (CCI+4)-intoxication in rats by the experimental methodsin vitro andin vivo. Tectorigenin and tectoridin exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by CCI4-intoxication in rats, as well as in a lipid peroxidation causing a significant decrease in malondialdehyde (MDA) production by thiobarbituric acid (TBA)-reactant assay. Both compounds also showed strong increase in the antioxidant enzymes such as hepatic cytosolic superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-px) activities in CCI4-intoxicated rats. These results suggested that tectorigenin and tectoridin isolated from the rhizomes ofB. chinensis possess not only the antioxidative, but also the hepatoprotective activities in CCI4-intoxicated rats.

引用

页码：184 / 188

页数：4

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