Free fatty acids and insulin secretion in humans

被引：51

作者：

Boden G. ^{[1
]}

机构：

[1] Division of Endocrinology/Diabetes/Metabolism, Temple University School of Medicine, Philadelphia, PA 19140

来源：

Current Diabetes Reports | 2005年 / 5卷 / 3期

关键词：

Free Fatty Acid; Insulin Secretion; Free Fatty Acid Level; Plasma Free Fatty Acid; Stimulate Insulin Secretion;

D O I：

10.1007/s11892-005-0004-5

中图分类号：

学科分类号：

摘要：

Acute increases in plasma levels of long-chain fatty acids raise plasma insulin levels by stimulating insulin secretion or by decreasing insulin clearance. In normal subjects, long-term elevations of fatty acids also stimulate insulin secretion. In fact, they increase insulin precisely to the degree needed to compensate for the fatty acid-induced insulin resistance. In contrast, in individuals who are genetically predisposed to develop type 2 diabetes (prediabetic subjects), the free fatty acid (FFA) stimulation of insulin secretion is not sufficient to fully compensate for the FFA-induced insulin resistance. Therefore, obesity, if associated with elevated fatty acid levels, may lead to hyperglycemia in prediabetic but not in normal individuals. Copyright © 2005 by Current Science Inc.

引用

页码：167 / 170

页数：3

共 24 条

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