Apoptosis in heart failure and the senescent heart

被引：74

作者：

Oliver Y. Bernecker

Fawzia Huq

E. Kevin Heist

Bruno K. Podesser

Roger J. Hajjar

机构：

[1] Massachusetts General Hospital,Program in Cardiovascular Gene Therapy, Cardiovascular Research Center and Cardiology Division

[2] Harvard Medical School,Ludwig Boltzmann Institute for Cardiosurgical Research

[3] University of Vienna,Cardiovascular Research Center

[4] Massachusetts General Hospital-East,undefined

来源：

Cardiovascular Toxicology | 2003年 / 3卷 / 3期

关键词：

Apoptosis; cell death; aging myocardium;

D O I：

10.1385/CT:3:3:183

中图分类号：

学科分类号：

摘要：

The progressive loss of cardiac myocytes by apoptotic cell death has been discussed as an important pathogenic component in the failing myocardium as well in the aging heart. The degree to which apoptosis contributes to myocyte loss in these conditions, however, is a controversial issue. This review focuses on the regulation of apoptosis, evidence implicating apoptosis as a mechanism for the progression and development of heart failure, the role of apoptotic death in senescent cardiac dysfunction, as well as on the problems of detection of apoptosis.

引用

页码：183 / 190

页数：7

共 179 条

[1]

Borner C.(1999)Apoptosis without caspases: an inefficient molecular guillotine? Cell Death Differ. 6 497-507

[2]

Monney L.(2003)Regulation of cardiac myocyte cell death Pharmacol. Ther. 97 223-261

[3]

Clerk A.(1999)Cell death in development Cell 96 245-254

[4]

Cole S.M.(1972)Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics Br. J. Cancer 26 239-257

[5]

Cullingford T.E.(1980)Cell death: the significance of apoptosis Int. Rev. Cytol. 68 251-306

[6]

Harrison J.G.(2000)Apoptosis and heart failure: A critical review of the literature Circ. Res. 86 1107-1113

[7]

Jormakka M.(1996)Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats Am. J. Physiol. 271 H1215-H1228

[8]

Valks D.M.(1998)Apoptosis: basic mechanisms and implications for cardiovascular disease Circ. Res. 82 1111-1129

[9]

Vaux D.L.(1996)Apoptosis in myocytes in end-stage heart failure N. Engl. J. Med. 335 1182-1189

[10]

Korsmeyer S.J.(1997)Apoptosis in the failing human heart N. Engl. J. Med. 336 1131-1141

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