Differential expression of TGF-β isoforms during postlactational mammary gland involution

被引：39

作者：

Faure E. ^{[1
]}

Heisterkamp N. ^{[1
]}

Groffen J. ^{[1
]}

Kaartinen V. ^{[2
]}

机构：

[1] Section of Molecular Carcinogenesis, Division of Hematology and Oncology, Childrens Hosp. Los Angeles Res. I., Los Angeles, CA 90027

[2] Developmental Biology Program, Department of Pathology, Mail Stop #54, Los Angeles, CA 90027

来源：

Cell and Tissue Research | 2000年 / 300卷 / 1期

关键词：

Extracellular matrix; Mouse [B6CBA(F[!sub]1[!/sub]); Postlactational involution; Remodeling; TGF-β;

D O I：

10.1007/s004410000183

中图分类号：

学科分类号：

摘要：

After cessation of lactation, the mammary gland undergoes involution, which is characterized by a massive epithelial cell death and proteolytic degradation of the extracellular matrix. Whereas the expression patterns and also the function of TGF-β isoforms during mammary gland branching morphogenesis and lactation are well understood, their expression during postlactational involution and therefore a possible role in this process is poorly known. In this study we show that TGF-β3 expression is dramatically induced (>fivefold) during mouse mammary gland involution when compared to that of virgin mouse, reaching a maximal expression level at day 4 after weaning. In contrast, other TGF-β isoforms do not display significant increase in expression during involution (TGF-β1, 1.3-fold and TGF-β2, <1.5-fold) when compared to that of virgin or lactating mice. During mammary gland involution, TGF-β3 is expressed in the epithelial layer and particularly in myoepithelial cells. A comparison of the kinetics of TGF-β3 expression to that of programmed cell death and degradation of the basement membrane suggests that TGF-β3 functions in the remodeling events of the extracellular matrix during the second stage of involution.

引用

页码：89 / 95

页数：6

共 24 条

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