Localization of human β-defensin 3 mRNA in normal oral epithelium, leukoplakia, and lichen planus: An in situ hybridization study

被引：7

作者：

Michiko Nishimura

Yoshihiro Abiko

Kaoru Kusano

Mami Yamazaki

Masato Saitoh

Itaru Mizoguchi

Yoshinori Jinbu

Tadahide Noguchi

Tohru Kaku

机构：

[1] Department of Oral Pathology, School of Dentistry, Hlth. Sci. University of Hokkaido

[2] Department of Pediatric Dentistry, Hlth. Sci. University of Hokkaido, Hokkaido

[3] Department of Orthodontics, School of Dentistry, Hlth. Sci. University of Hokkaido, Hokkaido

[4] Dept. of Dentistry and Oral Surgery, Jich Medical School, Tochigi

来源：

Medical Electron Microscopy | 2003年 / 36卷 / 2期

关键词：

Antimicrobial peptide; Leukoplakia; Lichen planus; Oral epithelium; β-Defensin; 3;

D O I：

10.1007/s00795-002-0206-8

中图分类号：

学科分类号：

摘要：

Human β-defensin 3 (hBD-3), an antimicrobial peptide, is produced by various epithelial and some nonepithelial tissues. hBD-3 mRNA is widely expressed in oral tissues, including oral epithelium and the salivary glands. Although the localization of hBD-1 and hBD-2 has been well demonstrated in tissue sections, the localization pattern of hBD-3 has not yet been shown. In the present study, we investigated the expression pattern of hBD-3 mRNA by in situ hybridization using specific RNA probes; the signal for hBD-3 was detected in upper spinous and granular layers in normal oral epithelium. In cases of leukoplakia, a strong signal of hBD-3 mRNA was observed in the granular layer. In lichen planus, the signal was strongly detected in the spinous and suprabasal layers. The signals were stronger than those of either normal oral epithelium or leukoplakia. The results indicate that the localization pattern of hBD-3 is very similar to that of hBD-2. hBD-2 and hBD-3 may function together or compensate each other for expressional loss.

引用

页码：94 / 97

页数：3

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