UK clinical guideline for the prevention and treatment of osteoporosis

被引：481

作者：

Gregson, Celia L. ^{[1
,2
]}

Armstrong, David J. ^{[3
]}

Bowden, Jean ^{[1
]}

Cooper, Cyrus ^{[4
,5
,6
,7
]}

Edwards, John ^{[8
,9
]}

Gittoes, Neil J. L. ^{[10
,11
]}

Harvey, Nicholas ^{[4
,5
,6
]}

Kanis, John ^{[12
,13
]}

Leyland, Sarah ^{[14
]}

Low, Rebecca ^{[15
]}

McCloskey, Eugene ^{[16
]}

Moss, Katie ^{[17
]}

Parker, Jane ^{[1
]}

Paskins, Zoe ^{[18
,19
]}

Poole, Kenneth ^{[20
]}

Reid, David M. ^{[21
]}

Stone, Mike ^{[22
]}

Thomson, Julia ^{[14
]}

Vine, Nic ^{[1
]}

Compston, Juliet ^{[23
]}

机构：

[1] Univ Bristol, Musculoskeletal Res Unit, Bristol Med Sch, Southmead Hosp, Learning & Res Bldg, Bristol BS10 SNB, Avon, England

[2] Royal United Hosp NHS Fdn Trust, Bath, Avon, England

[3] Ulster Univ, Nutr Innovat Ctr Food & Hlth, Western Hlth & Social Care Trust NI, Belfast, Antrim, North Ireland

[4] Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, Hants, England

[5] Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England

[6] Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England

[7] Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, England

[8] Keele Univ, Primary Care Ctr Versus Arthrit, Sch Med, Keele, Staffs, England

[9] Wolstanton Med Ctr, Newcastle Upon Tyne, Tyne & Wear, England

[10] Univ Hosp Birmingham, Queen Elizabeth Hosp, Ctr Endocrinol Diabet & Metab, Birmingham, W Midlands, England

[11] Univ Birmingham, Birmingham, W Midlands, England

[12] Australian Catholic Univ, Mary McKillop Inst Hlth Res, Melbourne, Vic, Australia

[13] Univ Sheffield, Ctr Metab Bone Dis, Sheffield, S Yorkshire, England

[14] Royal Osteoporosis Soc, Bath, Avon, England

[15] Nuffield Orthopaed Ctr, Abingdon & Specialty Doctor Metab Bone Dis, Marcham Rd Hlth Ctr, Oxford, England

[16] Univ Sheffield, MRC Versus Arthrit Ctr Integrated Res Musculoskel, Dept Oncol & Metab, Mellanby Ctr Musculoskeletal Res, Sheffield, S Yorkshire, England

[17] St Georges Univ Hosp, London, England

[18] Keele Univ, Sch Med, Keele, Staffs, England

[19] Midlands Partnership NHS Fdn Trust, Haywood Acad Rheumatol Ctr, Haywood Hosp, Stoke On Trent, Staffs, England

[20] Univ Cambridge, Dept Med, Cambridge, England

[21] Univ Aberdeen, Aberdeen, Scotland

[22] Cardiff & Vale Univ Hlth Board, Univ Hosp Llandough, Llandough, Wales

[23] Univ Cambridge, Sch Clin Med, Cambridge, England

来源：

ARCHIVES OF OSTEOPOROSIS | 2022年 / 17卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

Osteoporosis; Fracture; NOGG; Guideline; BONE-MINERAL DENSITY; GLUCOCORTICOID-INDUCED OSTEOPOROSIS; HIP FRACTURE PATIENTS; CORTICOSTEROID-INDUCED OSTEOPOROSIS; VERTEBRAL COMPRESSION FRACTURES; YEARLY ZOLEDRONIC ACID; QUALITY-OF-LIFE; AGED; 50; YEARS; POSTMENOPAUSAL WOMEN; DOUBLE-BLIND;

D O I：

10.1007/s11657-022-01061-5

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The National Osteoporosis Guideline Group (NOGG) has revised the UK guideline for the assessment and management of osteoporosis and the prevention of fragility fractures in postmenopausal women, and men age 50 years and older. Accredited by NICE, this guideline is relevant for all healthcare professionals involved in osteoporosis management. Introduction The UK National Osteoporosis Guideline Group (NOGG) first produced a guideline on the prevention and treatment of osteoporosis in 2008, with updates in 2013 and 2017. This paper presents a major update of the guideline, the scope of which is to review the assessment and management of osteoporosis and the prevention of fragility fractures in postmenopausal women, and men age 50 years and older. Methods Where available, systematic reviews, meta-analyses and randomised controlled trials were used to provide the evidence base. Conclusions and recommendations were systematically graded according to the strength of the available evidence. Results Review of the evidence and recommendations are provided for the diagnosis of osteoporosis, fracture-risk assessment and intervention thresholds, management of vertebral fractures, non-pharmacological and pharmacological treatments, including duration and monitoring of anti-resorptive therapy, glucocorticoid-induced osteoporosis, and models of care for fracture prevention. Recommendations are made for training; service leads and commissioners of healthcare; and for review criteria for audit and quality improvement. Conclusion The guideline, which has received accreditation from the National Institute of Health and Care Excellence (NICE), provides a comprehensive overview of the assessment and management of osteoporosis for all healthcare professionals involved in its management. This position paper has been endorsed by the International Osteoporosis Foundation and by the European Society for the Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases.

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