High-density lipoprotein: Is it always atheroprotective?

被引：59

作者：

Ansell B.J. ^{[1
]}

Fonarow G.C. ^{[1
]}

Fogelman A.M. ^{[1
]}

机构：

[1] Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095

来源：

Current Atherosclerosis Reports | 2006年 / 8卷 / 5期

关键词：

Cholesteryl Ester Transfer Protein; Acute Phase Response; Arterioscler Thromb Vasc Biol; Reverse Cholesterol Transport; Coronary Heart Disease Risk Equivalent;

D O I：

10.1007/s11883-006-0038-4

中图分类号：

学科分类号：

摘要：

High-density lipoproteins (HDLs) are appropriately recognized for their many atheroprotective functions, including reverse cholesterol transport, as well as anti-oxidant, anti-inflammatory, and antithrombotic effects. Furthermore, the inverse relationship between HDL cholesterol and atherosclerosis is well documented in many populations. However, there is an increasing body of evidence that there are circumstances in which HDL may not be protective, and may in fact paradoxically promote vascular inflammation and oxidation of low-density lipoproteins. Recent studies have provided insight as to specific chemical modifications and structural changes within HDL associated with this phenotype. The presence of proinflammatory HDL coincides with conditions associated with chronic systemic inflammation, including atherosclerosis. Copyright © 2006 by Current Science Inc.

引用

页码：405 / 411

页数：6

共 52 条

[1] Castelli W.P., Garrison R.J., Wilson P.W., Et al., Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study, JAMA, 256, pp. 2835-2838, (1986)
[2] Sirtori C.R., Calabresi L., Franceschini G., Et al., Cardiovascular status of carriers of the apolipoprotein A-IMilano mutant: The Limone sul Garda Study, Circulation, 103, pp. 1949-1954, (2001)
[3] Bruce C., Sharp D.S., Tall A.R., Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia, J Lipid Res, 39, pp. 1071-1078, (1998)
[4] Zhong S., Sharp D.S., Grove J.S., Et al., Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL Levels, J Clin Invest, 97, pp. 2917-2923, (1996)
[5] Ansell B.J., Navab M., Hama S., Et al., Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment, Circulation, 108, pp. 2751-2756, (2003)
[6] Asztalos B.F., Cupples L.A., Demissie S., Et al., High-density lipoprotein subpopulation profile and coronary heart disease prevalence in male participants of the Framingham Offspring Study, Arterioscler Thromb Vasc Biol, 24, pp. 2181-2187, (2004)
[7] Brewer Jr. H.B., High-density lipoproteins: A new potential therapeutic target for the prevention of cardiovascular disease, Arterioscler Thromb Vasc Biol, 24, pp. 387-391, (2004)
[8] Van Lenten B.J., Navab M., Shih D., Et al., The role of high-density lipoproteins in oxidation and inflammation, Trends Cardiovasc Med, 11, pp. 155-161, (2001)
[9] Ferretti G., Bacchetti T., Negre-Salvayre A., Et al., Structural modifications of HDL and functional consequences, Atherosclerosis, 184, (2006)
[10] Kontush A., Chantepie S., Chapman M.J., Small, dense HDL particles exert potent protection of atherogenic LDL against oxidative stress, Arterioscler Thromb Vasc Biol, 23, pp. 1881-1888, (2003)

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