Prognostic value of p53 accumulation in epithelial ovarian carcinomas

被引：11

作者：

Berker B. ^{[1
]}

Dunder I. ^{[1
]}

Ensari A. ^{[1
]}

Cengiz S.D. ^{[1
]}

机构：

[1] Department of Obstetrics, Faculty of Medicine, Ankara University, Asagiayranci, 06540 Ankara

来源：

Archives of Gynecology and Obstetrics | 2002年 / 266卷 / 4期

关键词：

Apoptosis; Epithelial ovarian carcinoma; p53; immunoreactivity; Prognostic markers;

D O I：

10.1007/s004040100235

中图分类号：

学科分类号：

摘要：

Aim: To evaluate the prognostic significance of p53 expression in epithelial ovarian carcinomas (EOC), and to look for correlations between p53 and other disease parameters. Material and methods: Immunohistochemical techniques were used to evaluate p53 expression in paraffin-embedded tissue specimens of 50 EOC cases. Results: p53 immunoreactivity was present in 33 of the 50 cases (66%). The expression of the p53 did not show any association with the tumor histologic type, grade or with the disease stage. However, p53 accumulation was significantly more prevalent among tumors with high mitotic index (p<0.01). Although median survival was low in the p53 negative cases, this biologic marker did not reveal as an independent prognostic factor in Cox's regression analysis. Conclusion: Abnormalities of p53 expression which is an inducer of apoptosis occur commonly in EOC. Although we could not find it as an independent prognostic factor, p53 expression should be studied in larger series to reveal its accurate prognostic significance.

引用

页码：205 / 209

页数：4

共 19 条

[1]

Berchuck A., Kohler M.F., Hopkins M.P., Et al., Overexpression of p53 is not a feature of benign and early stage borderline epithelial ovarian tumors, Gynecol Oncol, 52, pp. 232-236, (1994)

[2]

Bosari S., Giusuppe V., Umberto R., Paola B., p53 accumulation in ovarian carcinomas and its prognostic implications, Hum Pathol, 24, pp. 1175-1179, (1993)

[3]

Diebold J., Baretton G., Felchner M., Bcl-2 expression, p53 accumulation, and apoptosis in ovarian carcinomas, Am J Clin Pathol, 105, pp. 341-349, (1996)

[4]

Eccles D.M., Brett L., Lessells A., Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma, Br J Cancer, 65, pp. 40-44, (1992)

[5]

Greenblatt M.S., Bennett W.P., Hollstein M., Harris C.C., Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis, Cancer Res, 54, pp. 4855-4878, (1994)

[6]

Henderson B.E., Ross R.K., Pike M.C., Toward the primary prevention of cancer, Science, 254, pp. 1131-1138, (1991)

[7]

Henriksen R., Strang P., Wilander E., Backstrom T., Tribukait B., Oberg K., p53 expression in epithelial ovarian neoplasms: Relationship to clinical and pathological parameters, Ki-67 expression and flow cytometry, Gynecol Oncol, 53, pp. 301-306, (1994)

[8]

Hollstein M., Sidransky D., Vogelstein B., Harris C.C., P53 mutations in human cancers, Science, 253, pp. 49-53, (1991)

[9]

Kacinski B.M., Chambers S.K., Molecular biology of cancer, Curr Opin Oncol, 3, pp. 889-900, (1991)

[10]

King L.A., Okagaki T., Gallup D.G., Twiggs L.B., Messing M.J., Carson L.F., Mitotic count, nuclear atypia, and immunohistochemical determination of Ki-67, c-myc, p21-ras, c-erbB2, and p53 expression in granulosa cell tumors of the ovary: Mitotic count and Ki-67 are indicators of poor prognosis, Gynecol Oncol, 61, pp. 227-232, (1996)

← 1 2 →