Human immunodeficiency virus type 1 compartmentalization in the central nervous system

被引：15

作者：

Petito C.K. ^{[1
]}

机构：

[1] Department of Pathology, Univ. of Miami School of Medicine, Miami

来源：

Journal of NeuroVirology | 2004年 / 10卷 / Suppl 1期

关键词：

Chemokine receptors; Choroid plexus; Microarrays; Neurons; T lymphocytes;

D O I：

10.1080/753312748

中图分类号：

学科分类号：

摘要：

HIV-1 replicates in monocyte-derived cells in multiple organ systems; in the central nervous system, productive infection is confined to monocyte lineage cells in the brain. In addition, productive viral infection takes place in the choroid plexus, where the incidence of infection is actually higher than in brain and is present prior to the onset of AIDS and immunosuppression. Restricted or latent infection occurs in astrocytes and neurons. The presence of perineuronal CD4+ lymphocytes, as well as activated microglia, support the potential for a trans-receptor mechanism of viral entry whereas intrinsic gene profiles do not appear to participate in conferring selective neuronal vulnerability or resistance to infection. © 2004 Journal of NeuroVirology.

引用

页码：21 / 24

页数：3

共 33 条

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