The effect of allergen exposure in early childhood on the development of atopy

被引：15

作者：

Custovic A. ^{[1
]}

Murray C.S. ^{[1
]}

机构：

[1] North West Lung Centre, Wythenshawe Hospital, Southmoor Road, Manchester

来源：

Current Allergy and Asthma Reports | 2002年 / 2卷 / 5期

关键词：

Allergen Exposure; Allergy Clin Immunol; Asthma; Inhalant Allergen; Mite Allergen;

D O I：

10.1007/s11882-002-0076-0

中图分类号：

学科分类号：

摘要：

While there is good evidence for the association between allergen exposure and disease severity in sensitized individuals, and allergen exposure and development of sensitization, the relationship between allergen exposure and development of allergic disease is as yet unresolved. A protective effect of cat ownership on sensitization and allergic disease has been reported. The dose-response relationship between allergen exposure and sensitization may be different for different allergens (eg, linear for mite, bell-shaped for cat). Exposure to a high level of cat allergen may result in a modified Th2 response characterized by the presence of IgG4 antibody to cat proteins without IgE response, which could be regarded as a form of tolerance. The long-term prospective follow-up of well-defined cohorts with objective exposure and outcome measures will elucidate the complex relationship between environmental allergen exposures, sensitization, and asthma. © 2002, Current Science Inc.

引用

页码：417 / 423

页数：6

共 45 条

[1]

Pearce N., Pekkanen J., Beasley R., How much asthma is really attributable to atopy?, Thorax, 54, pp. 268-272, (1999)

[2]

Pearce N., Douwes J., Beasley R., Is allergen exposure the major primary cause of asthma?, Thorax, 55, pp. 424-431, (2000)

[3]

Simpson B.M., Custovic A., Simpson A., Et al., NAC Manchester Asthma and Allergy Study (NACMAAS): risk factors for asthma and allergic disorders in adults, Clin Exp Allergy, 31, pp. 391-399, (2001)

[4]

Wahn U., Lau S., Bergmann R., Et al., Indoor allergen exposure is a risk factor for sensitization during the first three years of life, J Allergy Clin Immunol, 99, pp. 763-769, (1997)

[5]

Kuehr J., Frischer T., Meinert R., Et al., Mite allergen exposure is a risk for the incidence of specific sensitization, J Allergy Clin Immunol, 94, pp. 44-52, (1994)

[6]

Lau S., Illi S., Sommerfeld C., Et al., Early exposure to house dust mite and cat allergens and development of childhood asthma: a cohort study, Lancet, 356, pp. 392-397, (2000)

[7]

Sporik R., Squillace S.P., Ingram J.M., Et al., Mite, cat and cockroach exposure, allergen sensitization and asthma in children: a case-control study of three schools, Thorax, 54, pp. 675-680, (1999)

[8]

Hesselmar B., Aberg N., Aberg B., Et al., Does early exposure to cat or dog protect against later allergy development, Clin Exp Allergy, 29, pp. 611-617, (1999)

[9]

Lau S., Falkenhorst G., Weber A., Et al., High mite-allergen exposure increases the risk of sensitization in atopic children and young adults, J Allergy Clin Immunol, 84, pp. 718-725, (1989)

[10]

Huss K., Adkinson N.F.J., Eggleston P.A., Et al., House dust mite and cockroach exposure are strong risk factors for positive allergy skin test responses in the Childhood Asthma Management Program, J Allergy Clin Immunol, 107, pp. 48-54, (2001)

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