Evaluation of bone mineral density in children with diabetes mellitus

被引：25

作者：

Ersoy B. ^{[1
,4
]}

Gökşen D. ^{[2
]}

Darcan S. ^{[1
]}

Mavi E. ^{[1
]}

Öztürk C. ^{[3
]}

机构：

[1] Dept. of Pediatric Endocrinology, Ege University, Faculty of Medicine, Izmir

[2] Division of Pediatrics, Ege University, Faculty of Medicine, Izmir

[3] Div. of Phys. Ther. and Rehab., Ege University, Faculty of Medicine, Izmir

[4] Izmir, 108/35 sokak No : 51 /36, A. Apt. E.

来源：

The Indian Journal of Pediatrics | 1999年 / 66卷 / 3期

关键词：

Bone mineral density; Insulin dependent diabetes mellitus;

D O I：

10.1007/BF02845528

中图分类号：

学科分类号：

摘要：

Multiple studies have documented reduction in peripheral bone mass in children with insulin dependent diabetes mellitus (IDDM). In this study, the bone mineral density (BMD) of the lumbar vertebrae (L2-L4) was measured by dual photon absorptiometry in 14 female and 16 male diabetic patients of age 11 to 16 years with varying clinical duration. Twenty three children between 11 to 16 years with normal anthropometric measurements between 10th and 97th percentile and no known history of metabolic bone disease served as a control group. BMD values, weight, height, body mass index, metabolic, biochemical and growth parameters of the study group were compared with those of the control group. BMD (L2 AP 0.732 ± 0.15 gm/cm2, L2 lateral 0.534 ± 0.09 gm/cm2in the study group and 0.812 ± 0.63 gm/cm2 and 0.619 ± 0.20 gm/cm2 in the control group) and osteocalcin (10.10 ± 3.40 ng/ml and 23.12 ± 2.74 ng/ml in diabetes and control respectively) levels were significantly lower in diabetic parents (p < 0.05, p < 0.01 respectively). Within the study group BMD correlated positively with age but not with the duration of the disease nor with the level of metabolic control.

引用

页码：375 / 379

页数：4

共 19 条

[1] Marvin E.L., Vincenza C.B., Louis V.A., Effects of diabetes mellitus in juvenile and adult onset diabetes, N Engl J Med, 294, pp. 241-245, (1976)
[2] Stephan W.P., David P.M., Danial F., An D.T., Gerald W.O., Ben H.B., Bone mineral density of the lumbar vertebrae in children and adolescents with insulin-dependent diabetes mellitus, J Pediatr, 120, pp. 541-545, (1992)
[3] Stephan W.P., David P.M., Daniel F., Judy L.P., Margaret G.M., Ben H.B., Spinal bone mineral density in children aged 5.00 through 11.99 years, AJDC, 144, pp. 1346-1348, (1990)
[4] Siu L.H., Solomon E., Conrad C.J., A prospective study of bone mass in patients with type 1 diabetes, J Clin Endocrinol Metab, 60, pp. 74-80, (1985)
[5] Catherine G., Pierre B., Louis D., Pierre C., Pierre J.M., Pierre D.D., Measurement of bone mineral content of the lumbar spine by dual energy X-ray absorptiometry in normal children. Correlations with growth parameters, J Clin Endocrinol Metab, 70, pp. 1330-1333, (1990)
[6] Hosada K., Kanzaki S., Eguchi H., Et al., Secretion of osteocalcin and its propeptide from human osteoblastic cells : Dissociation of the secretory patterns of osteocalcin and its propeptide, J Bone Miner Res, 8, pp. 553-565, (1993)
[7] Rio D.L., Carrascosa A., Pons F., Gusinye M., Yeste D., Domenech M.F., Bone mineral density of lumbar spine in white mediterranean Spanish children and adolescents : Changes related to age, sex, and puberty, Pediatr Res, 35, pp. 362-366, (1994)
[8] Waud C.E., Markes S.C., Lev R., Baran D.T., Bone mineral density in the femur and lumbar vertebrae decreases after twelve weeks of diabetes in spontaneously diabetic prone BB/Worcester rats, Calcif Tissue Int, 54, pp. 237-240, (1994)
[9] Roe T.F., Mora S., Costin G., Et al., Vertebral bone density in insulin dependent diabetic children, Metabolism, 40, pp. 967-971, (1991)
[10] Scott D., Robins S.P., Nicol P., Chen X.B., Buchan W., Effects of low phosphate intake on bone mineral metabolism and microbial protein systhesis in lambs, Exp Physicol, 79, 2, pp. 183-187, (1994)

← 1 2 →