Oxygen-regulated transcription factors and their role in pulmonary disease

被引：121

作者：

Semenza G.L. ^{[1
]}

机构：

[1] Institute of Genetic Medicine and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

来源：

Respiratory Research | / 1卷 / 3期

基金：

美国国家卫生研究院;

关键词：

EGR-1; HIF-1; NF-IL6; Vascular remodeling;

D O I：

10.1186/rr27

中图分类号：

学科分类号：

摘要：

The transcription factors nuclear factor interleukin-6 (NF-IL6), early growth response-1 (EGR-1) and hypoxia-inducible factor-1 (HIF-1) have important roles in the molecular pathophysiology of hypoxia-associated pulmonary disease. NF-IL6 controls the production of interleukin (IL)-6 in vascular endothelial cells, which may have anti-inflammatory activity by counteracting effects of IL-1 and IL-8. EGR-1 controls the production of tissue factor by macrophages, which triggers fibrin deposition in the pulmonary vasculature. HIF-1 activates the expression of the vasoconstrictor endothelin-1 in vascular endothelial cells. Angiotensin II induces HIF-1 expression and hypertrophy of pulmonary arterial smooth muscle cells. HIF-1 might therefore have multiple roles in the pathogenesis of pulmonary vascular remodeling. © 2000 Current Science Ltd.

引用

页码：159 / 162

页数：3

共 25 条

[1]

Semenza G.L., Perspectives on oxygen sensing., Cell, 98, pp. 281-284, (1999)

[2]

Yan S.F., Tritto I., Pinsky D., Liao H., Huang J., Fuller G., Brett J., May L., Stern D., Induction of interleukin 6 (IL-6) by hypoxia in vascular cells: central role of the binding site for nuclear factor-IL6., J Biol Chem, 270, pp. 11463-11471, (1995)

[3]

Yan S.F., Zou Y.S., Mendelsohn M., Gao Y., Naka Y., Du Yan S., Pinsky D., Stern D., Nuclear factor interleukin 6 motifs mediate tissue-specific gene transcription in hypoxia., J Biol Chem, 272, pp. 4287-4294, (1997)

[4]

Karakurum M., Shreeniwas R., Chen J., Pinsky D., Yan S.D., Anderson M., Sunouchi K., Major J., Hamilton T., Kuwabara K., Et al., Hypoxic induction of interleukin-8 gene expression in human endothelial cells., J Clin Invest, 93, pp. 1564-1570, (1994)

[5]

Shreeniwas R., Koga S., Karakurum M., Pinsky D., Kaiser E., Brett J., Wolitzky B.A., Norton C., Plocinski J., Benjamin W., Et al., Hypoxia-mediated induction of endothelial cell interleukin-1α: an autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface., J Clin Invest, 90, pp. 2333-2339, (1992)

[6]

Michiels C., Arnould T., Remacle J., Endothelial cell responses to hypoxia: initiation of a cascade of cellular interactions., Biochim Biophys Acta, 1497, pp. 1-10, (2000)

[7]

Yan S.F., Zou Y.S., Gao Y., Zhai C., Mackman N., Lee S.L., Milbrandt J., Pinsky D., Kisiel W., Stern D., Tissue factor transcription driven by EGR-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia., Proc Natl Acad Sci USA, 95, pp. 8298-8303, (1998)

[8]

Lawson C.A., Yan S.D., Yan S.F., Liao H., Zhou Y.S., Sobel J., Kisiel W., Stern D.M., Pinsky D.J., Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation., J Clin Invest, 99, pp. 1729-1738, (1997)

[9]

Yan S.F., Lu J., Xu L., Zou Y.S., Tongers J., Kisiel W., Mackman N., Pinsky D.J., Stern D.M., Pulmonary expression of early growth response-1: biphasic time course and effect of oxygen concentration., J Appl Physiol, 88, pp. 2303-2309, (2000)

[10]

Yan S.F., Lu J., Zou Y.S., Kisiel W., Mackman N., Leitges M., Steinberg S., Pinsky D., Stern D., Protein kinase C-β and oxygen deprivation: a novel EGR-1-dependent pathway for fibrin deposition in hypoxemic vasculature., J Biol Chem, 275, pp. 11921-11928, (2000)

← 1 2 3 →