Sudden cardiac death without structural heart disease: Update on the long QT and Brugada syndromes

被引：18

作者：

Goldenberg I. ^{[1
]}

Moss A.J. ^{[1
]}

Zareba W. ^{[1
]}

机构：

[1] Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, NY 14642

来源：

Current Cardiology Reports | 2005年 / 7卷 / 5期

关键词：

Brugada Syndrome; QBUJFOUT XJUI; BTTPDJBUFE XJUI; IJHI SJTL; Normal Cardiac Morphology;

D O I：

10.1007/s11886-005-0088-1

中图分类号：

学科分类号：

摘要：

The long QT syndrome (LQTS) and the Brugada syndrome (BrS) are the most common genetic causes of malignant ventricular arrhythmias and sudden cardiac death in young patients with normal cardiac morphology. To date, more than 250 different mutations in seven genes have been identified as causing LQTS, whereas the only gene identified to be linked to BrS is SCN5A. In both syndromes, gene-specific mutations have been shown to be associated with specific phenotypic expressions. Risk stratification in LQTS and BrS is based mainly upon a constellation of electrocardiographic findings and a history of prior symptoms. In patients identified as high risk for arrhythmic mortality, the implantable cardioverter defibrillator is the most effective treatment and has been shown to provide near-complete protection during long-term follow-up. Copyright © 2005 by Current Science Inc.

引用

页码：349 / 356

页数：7

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