Contribution of cannabis and MDMA ("ecstasy") to cognitive changes in long-term polydrug users

被引：58

作者：

Dafters R.I. ^{[1
]}

Hoshi R. ^{[2
]}

Talbot A.C. ^{[1
]}

机构：

[1] Psychology Department, Glasgow University, Glasgow, G12 8QB

[2] Psychol., Sub-Dept. Clin. Hlth. P., University College London, London, WC1E 6BT, Gower Street

来源：

Psychopharmacology | 2004年 / 173卷 / 3-4期

关键词：

Cannabis; Human users; MDMA; Memory and attention effects;

D O I：

10.1007/s00213-003-1561-4

中图分类号：

学科分类号：

摘要：

Rationale: Establishing whether cognitive changes follow long-term use of MDMA ("ecstasy") in humans has been difficult because of possible confounds with other drug use, particularly cannabis. Convincing evidence may be only obtained using experimental designs that account for such confounds. Objective: In the present study, cognitive/behavioural measures were used to investigate whether long-term MDMA use or long-term cannabis use is responsible for the changes sometimes observed in recreational MDMA users. Method: Tests of attention and memory were administered to subjects who used both MDMA and cannabis, cannabis only, or neither drug. Results: The main finding was that cannabis users, whether or not they also used MDMA, showed significantly impaired memory function on word free-recall and on immediate and delayed story recall compared to non-users. Conclusions: The findings high-light the importance of controlling for other drug use (particularly cannabis) when investigating persistent effects of MDMA in humans. © Springer-Verlag 2003.

引用

页码：405 / 410

页数：5

共 36 条

[1]

Beck A.T., Epstein N., Brown G., Steer R.A., An inventory for measuring clinical anxiety: Psychometric properties, J Consult Clin Psychol, 56, pp. 893-897, (1988)

[2]

Block R.I., Ghoneim M.M., Effects of chronic marijuana use on human cognition, Psychopharmacology, 110, pp. 219-228, (1993)

[3]

Cairns E., Cammock T., Development of a more reliable version of the matching familiar figures test, Dev Psychol, 13, pp. 555-560, (1978)

[4]

Callow N., Use of snowballing technique to investigate subjective mood and personality traits associated with ecstasy, Br Psychol Soc, 5, (1996)

[5]

Croft R.J., Mackay A.J., Mills A.T.D., Gruzelier J.G.H., The relative contribution of ecstasy and cannabis to cognitive impairment, Psychopharmacology, 153, pp. 373-379, (2001)

[6]

Curran H.V., Travill R.A., Mood and cognitive effects of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"): Weekend "high" followed by mid-week "low, Addiction, 92, pp. 821-831, (1997)

[7]

Dafters R.I., Duffy F., O'Donnell P.J., Bouquet C., Level of use of 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in humans correlates with EEG power and coherence, Psychopharmacology, 145, pp. 82-90, (1999)

[8]

Davison D., Parrott A.C., Ecstasy in recreational users: Self-reported psychological and physiological effects, Hum Psychopharmacol Clin Exp, 12, pp. 91-97, (1997)

[9]

Eysenck H.J., Eysenck S.B.G., The Eysenk Personality Questionaire - Revised (Short), (1991)

[10]

Eysenck H.J., Eysenck S.B.G., The Impulsiveness (IVE) Questionnaire, (1991)

← 1 2 3 4 →