HIV diversity, molecular epidemiology, and the role of recombination

被引：45

作者：

Kijak G.H. ^{[1
]}

McCutchan F.E. ^{[1
]}

机构：

[1] US Military HIV Research Program, Henry M. Jackson Foundation, Rockville, MD 20850

来源：

Current Infectious Disease Reports | 2005年 / 7卷 / 6期

关键词：

Human Immunodeficiency Virus Type; Molecular Epidemiology; Synonymous Codon; Recombinant Form; Acquir Immune;

D O I：

10.1007/s11908-005-0051-8

中图分类号：

学科分类号：

摘要：

The magnitude of the HIV pandemic and its extensive genetic variation may earn it a unique place among infectious agents. A high mutation rate and a rampant recombination are driving HIV's evolution. Nine subtypes and a variety of recombinant forms of HIV now exist. The source of recombinant forms is the multiple infection of target cells, which becomes highly significant when individuals become infected with two or more divergent strains. In the current paper, we re-examine the role of dual infection and recombination in the generation of HIV-1 diversity, both in individuals and on a global scale. The current molecular epidemiology of HIV-1 is reviewed, emphasizing the latest reports from regional epidemics. Copyright © 2005 by Current Science Inc.

引用

页码：480 / 488

页数：8

共 59 条

[1]

McCutchan F.E., Understanding the genetic diversity of HIV-1, AIDS, 14, SUPPL. 3, (2000)

[2]

Coffin J.M., Hughes S.H., Varmus H.E., Retroviruses, (1997)

[3]

Coffin J.M., HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy, Science, 267, pp. 483-489, (1995)

[4]

Brenner B., Turner D., Oliveira M., Et al., A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors, AIDS, 17, (2003)

[5]

Kijak G.H., Currier J.R., Tovanabutra S., Et al., Lost in translation: Implications of HIV-1 codon usage for immune escape and drug resistance, AIDS Rev., 6, pp. 54-60, (2004)

[6]

Jung A., Maier R., Vartanian J.P., Et al., Multiply infected spleen cells in HIV patients, Nature, 418, (2002)

[7]

Levy D.N., Aldrovandi G.M., Kutsch O., Shaw G.M., Dynamics of HIV-1 recombination in its natural target cells, Proc. Natl. Acad. Sci. U. S. A., 101, pp. 4204-4209, (2004)

[8]

Tovanabutra S., Beyrer C., Sakkhachornphop S., Et al., The changing molecular epidemiology of HIV type 1 among northern Thai drug users, 1999 to 2002, AIDS Res. Hum. Retroviruses, 20, pp. 465-475, (2004)

[9]

Arroyo M.A., Hoelscher M., Sateren W., Et al., HIV-1 diversity and prevalence differ between urban and rural areas in the Mbeya region of Tanzania, AIDS

[10]

Smith D.M., Richman D.D., Little S.J., HIV superinfection, J. Infect. Dis., 192, pp. 438-444, (2005)

← 1 2 3 4 5 6 →