New perspectives for tumor pathology provided by comparative genomic hybridization

被引：7

作者：

Oga A. ^{[1
]}

Kawauchi S. ^{[1
]}

Izumi H. ^{[1
]}

Ping L.X. ^{[1
]}

Furuya T. ^{[1
]}

Sasaki K. ^{[1
]}

机构：

[1] Department of Pathology, Yamaguchi University, School of Medicine, Ube, Yamaguchi 755-8505

来源：

International Journal of Clinical Oncology | 2002年 / 7卷 / 3期

关键词：

Cancer; CGH; Chromosome; Comparative genomic hybridization; Solid tumor; Surgical pathology;

D O I：

10.1007/s101470200019

中图分类号：

学科分类号：

摘要：

Comparative genomic hybridization (CGH) allows rapid screening for DNA copy number gains and losses across the entire genome. CGH analyses have revealed a number of common aberrations and characteristics associated with specific tumor cells or pathogeneses. Recurrent aberrations suggest that tumor-related gene(s) may be located in such regions. Furthermore, some specific aberrations may serve as novel diagnostic features. Quantitative chromosomal analyses based on CGH have also provided stimulating information associated with chromosomal instability, genetic pathways, telomerase activity status, and DNA ploidy and have yielded valuable insights into tumor pathology. This review focuses on scientific advances facilitated by this technique.

引用

页码：133 / 137

页数：4

共 37 条

[1]

Lander E.S., Linton L.M., Birren B., Et al., Initial sequencing and analysis of the human genome, Nature, 409, pp. 860-921, (2001)

[2]

Venter J.C., Adams M.D., Myers E.W., Et al., The sequence of the human genome, Science, 291, pp. 1304-1351, (2001)

[3]

Cahill D.P., Lengauer C., Yu J., Et al., Mutations of mitotic checkpoint genes in human cancers, Nature, 392, pp. 300-303, (1998)

[4]

Kallioniemi A., Kallioniemi O.P., Sudar D., Et al., Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors, Science, 258, pp. 818-821, (1992)

[5]

Pinkel D., Segraves R., Sudar D., Et al., High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays, Nat Genet, 20, pp. 207-211, (1998)

[6]

Pollack J.R., Perou C.M., Alizadeh A.A., Et al., Genome-wide analysis of DNA copy-number changes using cDNA microarrays, Nat Genet, 23, pp. 41-46, (1999)

[7]

Schlegel J., Scherthan H., Arens N., Et al., Detection of complex genetic alterations in human glioblastoma multiforme using comparative genomic hybridization, J Neuropathol Exp Neurol, 55, pp. 81-87, (1996)

[8]

Nishizaki T., Kubota H., Harada K., Et al., Clinical evidence of distinct subgroups of astrocytic tumors defined by comparative genomic hybridization, Hum Pathol, 30, pp. 608-614, (2000)

[9]

Nishizaki T., Ozaki S., Harada K., Et al., Investigation of genetic alterations associated with the grade of astrocytic tumor by comparative genomic hybridization, Genes Chromosomes Cancer, 21, pp. 340-346, (1998)

[10]

Sallinen S.L., Sallinen P., Haapasalo H., Et al., Accumulation of genetic changes is associated with poor prognosis in grade II astrocytomas, Am J Pathol, 151, pp. 1799-1807, (1997)

← 1 2 3 4 →